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Generic Name: Paclitaxel (Protein-Bound Particles) Injection (PAK-li-tax-el)
Brand Name: Abraxane
Abraxane must be administered in an appropriate medical setting under close medical supervision. Patients with metastatic breast cancer who also have extremely low neutrophil (a type of white blood cell) counts should not use Abraxane . Frequent blood tests should be performed while you are using Abraxane to monitor for bone marrow suppression and serious infection. Do not substitute or interchange Abraxane with other forms of paclitaxel.
Abraxane is used for:
Treating breast cancer in certain patients. It may also be used for other types of cancer as determined by your doctor.
Abraxane is a chemotherapy medicine. It works by slowing or stopping cancer cells from dividing and growing, so they eventually die.
Do NOT use Abraxane if:
- you are allergic to any ingredient in Abraxane
- you have extremely low white blood cell counts (eg, extremely low neutrophil counts)
- you have shingles or chickenpox
Contact your doctor or health care provider right away if any of these apply to you.
Before using Abraxane :
Some medical conditions may interact with Abraxane . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, plan to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a bacterial or viral infection, HIV infection, liver or kidney problems, a history of heart problems or heart attack, bone
marrow problems, or blood problems (low platelet or neutrophil counts)
- if you are undergoing radiation therapy
- if you have ever had an allergic reaction to an insect sting
Some MEDICINES MAY INTERACT with Abraxane . Tell your health care provider if you are taking any other medicines, especially any of the following:
- Ketoconazole because side effects of Abraxane may be increased
- Warfarin or doxorubicin because side effects may be increased by Abraxane
This may not be a complete list of all interactions that may occur. Ask your health care provider if Abraxane may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Abraxane :
Use Abraxane as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Abraxane comes with an additional patient leaflet. Read it carefully and reread it each time you get Abraxane refilled.
- Abraxane is usually administered as an injection at your doctor"s office, hospital, or clinic. Ask your doctor or pharmacist any questions that you may have about Abraxane .
- If nausea, vomiting, diarrhea, or loss of appetite occurs, do not discontinue your medicine. Ask your doctor or pharmacist for ways to lessen these effects.
- Wear gloves while handling Abraxane .
- If you get Abraxane on your skin, rinse the area thoroughly with soap and water. If you get Abraxane in your eyes, nose, or mouth, flush the area thoroughly with water.
- If you miss a dose of Abraxane , contact your doctor immediately.
Ask your health care provider any questions you may have about how to use Abraxane .
Important safety information:
- Some patients develop redness or sores in the mouth or on the lips. These symptoms may occur a few days after treatment with Abraxane and usually decrease or disappear in 1 week. Talk with your doctor about proper mouth care and other ways to prevent or reduce this side effect.
- Abraxane may cause dizziness or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Abraxane . Using Abraxane alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
- Abraxane contains albumin, which comes from human blood. There is an extremely rare risk of developing a viral disease, or a central nervous system disease called Creutzfeldt-Jakob disease. No cases of viral disease or Creutzfeldt-Jakob disease from albumin have been identified.
- Abraxane may lower your body"s ability to
fight infection. Prevent infection by avoiding contact with people with colds or other infections. Notify your doctor of any signs of infection, including fever, sore throat, rashes, or chills. Also, do not touch your eyes or the inside of your nose unless you have thoroughly washed your hands first.
- Abraxane may reduce the number of blood cells that are needed for clotting. Report any unusual bleeding, bruising, blood in the stools, or dark, tarry stools immediately to your doctor.
- If you have not had chickenpox or measles, avoid contact with anyone who has either of these diseases or shingles.
- Check with your doctor before having immunizations (vaccinations).
- Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Abraxane .
- LAB TESTS, including blood counts and liver function tests, will be required to monitor your progress and check for side
effects. Be sure to keep all doctor and lab appointments.
- Use an effective form of birth control (eg, condoms) during sexual intercourse with a woman of childbearing age while you are using Abraxane .
- Women of childbearing age should use an effective form of birth control (eg, condoms) while using Abraxane .
- PREGNANCY AND BREAST-FEEDING: Abraxane has been shown to cause harm to the human fetus. If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using Abraxane during pregnancy. It is unknown if Abraxane is excreted in breast milk. Do not breast-feed while using Abraxane .
Possible side effects of Abraxane :
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
general feeling of discomfort; hair loss; mild discomfort, redness, or swelling at the injection site; mild joint or muscle pain; nausea;
numbness, tingling, or burning of your arms, hands, legs, or feet; redness and/or sores on the mouth or lips; unusual weakness or tiredness; vomiting.
Severe allergic reactions (rash; hives; difficulty swallowing or breathing;
tightness in the chest; flushing; swelling of the mouth, face, lips, tongue, or throat; hoarseness); blistering, swelling, redness, severe pain, or open sores on your skin or at the injection site; change in the amount of urine produced; chest pain; fast, slow, or irregular heartbeat; flu-like symptoms
(fever, chills, sore throat); pale appearance; redness, swelling, or tenderness in the calf; severe joint or muscle pain; severe nausea, vomiting or diarrhea;
severe numbness, tingling, or burning in the arms, hands, legs, or feet; severe stomach pain; swelling of
arms, hands, legs, or feet; sudden or severe dizziness, lightheadedness, or headache; unusual bruising or bleeding; vision changes or blurred vision.
This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately.
Proper storage of Abraxane :
Store Abraxane as directed on the prescription label. Keep Abraxane out of the reach of children and away from pets.
- If you have any questions about Abraxane , please
talk with your doctor, pharmacist, or other health care provider.
- Abraxane is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
This information is a summary only. It does not contain all information about Abraxane . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Issue Date: November 1, 2006
Database Edition 06.4.1.002
Copyright © 2006 Wolters Kluwer Health, Inc.
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