Danaparoid

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|Danaparoid

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DANAPAROID (Systemic)

Some commonly used brand names are:

In the U.S.—

  • Orgaran

Category

  • Antithrombotic

Description

Danaparoid (da-NAP-a-roid) is used to prevent deep venous thrombosis, a condition in which harmful blood clots form in the blood vessels of the legs. These blood clots can travel to the lungs and can become lodged in the blood vessels of the lungs, causing a condition called pulmonary embolism. Danaparoid is used for several days after hip replacement surgery, while you are unable to walk. It is during this time that blood clots are most likely to form. Danaparoid also may be used for other conditions as determined by your doctor.

Danaparoid is available only with your doctor"s prescription, in the following dosage form:

  • Parenteral
  • Injection (U.S.)

Before Using This Medicine

In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For danaparoid, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to danaparoid or heparin. Also tell your health care professional if you are allergic to any other substances, such as foods, especially pork or pork products, preservatives, or dyes.

Pregnancy—Danaparoid has not been studied in pregnant women. However, it has not been found to cause birth defects in animals.

Breast-feeding—It is not known whether this medicine passes into breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers who are using this medicine and who wish to breast-feed should discuss this with their doctor.

Children—Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of danaparoid in children with use in other age groups.

Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of danaparoid in the elderly with use in other age groups.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are using any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other medical problems—The presence of other medical problems may affect the use of danaparoid. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bleeding problems or
  • Heart infection or
  • High blood pressure (hypertension) or
  • Kidney disease or
  • Stomach or intestinal ulcer (active) or
  • Stroke—The risk of bleeding may be increased

Also, tell your doctor if you have received danaparoid before and had a reaction to it called thrombocytopenia (a low platelet count in the blood), or if new blood clots formed while you were receiving the medicine.

In addition, tell your doctor if you have recently had medical surgery . This may increase the risk of serious bleeding when you are taking danaparoid.

Proper Use of This Medicine

If you are using danaparoid at home, your health care professional will teach you how to inject yourself with the medicine. Be sure to follow the directions carefully. Check with your health care professional if you have any problems using the medicine .

Put used syringes in a puncture-resistant, disposable container , or dispose of them as directed by your health care professional.

Dosing—The dose of danaparoid may be different for different patients. Follow your doctor"s orders or the directions on the label . The following information includes only the average doses of danaparoid. If your dose is different, do not change it unless your doctor tells you to do so.

  • For injection dosage form:
    • For prevention of deep venous thrombosis (leg clots) and pulmonary embolism (lung clots):
      • Adults—750 anti-factor Xa units, injected under the skin, two times a day for up to fourteen days after surgery.
      • Children—Use and dose must be determined by your doctor.

Missed dose—If you miss a dose of this medicine, use it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage—To store this medicine:

  • Keep out of the reach of children.
  • Store away from heat and direct light.
  • Keep the medicine from freezing. Do not refrigerate.
  • Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

Precautions While Using This Medicine

Tell all your medical doctors and dentists that you are using this medicine .

Check with your doctor immediately if you notice any of the following side effects:

  • Bruising or bleeding, especially bleeding that is hard to stop. Bleeding inside the body sometimes appears as bloody or black, tarry stools, or faintness.
  • Back pain; burning, pricking, tickling, or tingling sensation; leg weakness; numbness; paralysis; or problems with bowel or bladder function.

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Stop using this medicine and check with your doctor immediately if any of the following side effects occur:

Less common

Bleeding gums; coughing up blood; difficulty in breathing or swallowing; dizziness; headache; increased menstrual flow or vaginal bleeding; nosebleeds; paralysis; prolonged bleeding from cuts; red or dark brown urine; red or black, tarry stools; shortness of breath; unexplained pain, swelling, or discomfort, especially in the chest, abdomen, joints, or muscles; unusual bruising; vomiting of blood or coffee ground-like material; weakness

Rare

Back pain; burning, pricking, tickling, or tingling sensation; leg weakness; numbness; problems with bowel or bladder function

Also, check with your doctor as soon as possible if any of the following side effects occur:

Less common

Fever

Rare

Skin rash

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:

More common

Pain at injection site

Less common

Constipation; nausea

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

Developed: 07/10/98

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