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Some commonly used brand names are:
In the U.S.—
Generic name product may be available in the U.S.
Danazol (DA-na-zole) may be used for a number of different medical problems. These include treatment of:
Danazol may also be used for other conditions as determined by your doctor.
This medicine is available only with your doctor"s prescription, in the following dosage form:
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For danazol, the following should be considered:
Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to danazol, androgens (male hormones), or anabolic steroids. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy—Danazol is not recommended for use during pregnancy, since it may cause a female baby to develop certain male characteristics.
Breast-feeding—Breast-feeding is not recommended while you are taking this medicine because it may cause unwanted effects in the baby.
Children—Danazol may cause male-like changes in female children and cause premature sexual development in male children. It may also slow or stop growth in any child.
Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of danazol in the elderly with use in other age groups, danazol has effects similar to androgens (male hormones). Androgens used in older males may increase the risk of developing prostate enlargement or cancer.
Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking danazol, it is especially important that your health care professional know if you are taking any of the following:
Other medical problems—The presence of other medical problems may affect the use of danazol. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This Medicine
In order for danazol to help you, it must be taken regularly for the full time of treatment as ordered by your doctor.
Dosing—The dose of danazol will be different for different patients. Follow your doctor"s orders or the directions on the label . The following information includes only the average doses of danazol. If your dose is different, do not change it unless your doctor tells you to do so.
The number of capsules that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problems for which you are taking danazol .
Missed dose—If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage—To store this medicine:
Precautions While Using This Medicine
Your doctor should check your progress at regular visits to make sure that this medicine does not cause unwanted effects.
Contact your doctor if you are a female and have a larger clitoris (sexual organ), deepening of your voice, or unnatural hair growth after taking danazol . Your doctor may advise you to stop taking the medicine so these effects do not get worse.
For patients with diabetes :
Danazol may cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness, or other discoloration of the skin, or a severe sunburn. When you begin taking this medicine:
If you have a severe reaction from the sun, check with your doctor .
If you are taking danazol for endometriosis or fibrocystic breast disease :
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
For both females and males
Acne; dark-colored urine; increased oiliness of hair or skin; muscle cramps or spasms; swelling of feet or lower legs; unusual tiredness or weakness; weight gain (rapid)
Bleeding gums; bloating, pain or tenderness of abdomen or stomach; blood in urine; burning, numbness, pain, or tingling in all fingers except the smallest finger; changes in vision; chest pain; chills; complete or partial numbness or weakness on one side of body; cough; coughing up blood; diarrhea; difficulty in speaking; difficulty in swallowing; discharge from nipple; eye pain; fast heartbeat; fever; headache; hives or other skin rash; joint pain; light-colored stools; loss of appetite (continuing); loss of muscle coordination; more frequent nosebleeds; muscle aches; nausea; purple- or red-colored, or other spots on body or inside the mouth or nose; restlessness; shortness of breath; sore throat; sweating; tingling, numbness, or weakness in legs, which may move upward to arms, trunk, or face; unusual bruising or bleeding; unusual tiredness, weakness, or general feeling of illness; vomiting; yellow eyes or skin
For females only
Decrease in breast size; irregular menstrual periods; weight gain
Enlarged clitoris; hoarseness or deepening of voice; unnatural hair growth
For males only
Changes in semen; decrease in size of testicles
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
For both females and males
Flushing or redness of skin; mood or mental changes; nervousness
Increased sensitivity of skin to sunlight
For females only
Burning, dryness, or itching of vagina; vaginal bleeding
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses may not be included in product labeling, danazol is used in certain patients with the following medical conditions:
Other than the above information, there is no additional information relating to proper use, precautions, or side effects for these uses.
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