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ANTIGLAUCOMA AGENTS, CHOLINERGIC, LONG-ACTING (Ophthalmic)
Some commonly used brand names are:
In the U.S.—
Other commonly used names are: DFP , difluorophate , dyflos , and ecothiopate
Demecarium, echothiophate, and isoflurophate are used in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia. They may also be used in the diagnosis of certain eye conditions, such as accommodative esotropia.
These medicines are available only with your doctor"s prescription, in the following dosage forms:
Before Using This Medicine
In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For demecarium, echothiophate, or isoflurophate, the following should be considered:
Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to demecarium, echothiophate, or isoflurophate. Also tell your health care professional if you are allergic to any other substances, such as preservatives.
Pregnancy—Because of the toxicity of these medicines in general, demecarium, echothiophate, and isoflurophate are not recommended during pregnancy.
Breast-feeding—Demecarium, echothiophate, and isoflurophate may be absorbed into the body. These medicines are not recommended during breast-feeding, because they may cause unwanted effects in nursing babies. It may be necessary for you to use another medicine or to stop breast-feeding during treatment. Be sure you have discussed the risks and benefits of the medicine with your doctor.
Children—Demecarium, echothiophate, or isoflurophate can cause serious side effects in any patient. When this medicine is used for a long time, eye cysts may occur. These eye cysts occur more often in children than in adults. Therefore, it is especially important that you discuss with the child"s doctor the good that this medicine may do as well as the risks of using it.
Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of these medicines in the elderly with use in other age groups. However, demecarium, echothiophate, or isoflurophate can cause serious side effects in any patient.
Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking demecarium, echothiophate, or isoflurophate, it is especially important that your health care professional know if you are taking any of the following:
Pesticides or insecticides—Make sure you tell your doctor if you have been exposed recently to pesticides or insecticides.
Other medical problems—The presence of other medical problems may affect the use of demecarium, echothiophate, or isoflurophate. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This Medicine
To use the ophthalmic solution (eye drops) form of this medicine:
To use the ophthalmic ointment (eye ointment) form of this medicine:
It is very important that you use this medicine only as directed . Do not use more of it and do not use it more often than your doctor ordered. To do so may increase the chance of too much medicine being absorbed into the body and the chance of side effects.
If the applicator tip touches any surface (including the eye), it may become contaminated with bacteria, which may increase the chance of developing an eye infection. If you think the applicator has become contaminated, notify your doctor immediately.
Eye ointment usually causes blurred vision for a short time after you use it, and eye drops containing these medicines may affect your vision for several hours after you use them. Therefore, ask your doctor if the dose (or one of the doses if you use more than 1 dose a day) can be used at bedtime.
Dosing—The doses of these medicines will be different for different patients. Follow your doctor"s orders or the directions on the label . The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.
Missed dose—If you miss a dose of this medicine and your dosing schedule is:
If your dosing schedule is different from all of the above and you miss a dose of this medicine, or if you have any questions about this, check with your doctor.
Storage—To store this medicine:
Precautions While Using This Medicine
If you are using this medicine for glaucoma, your doctor should check your eye pressure at regular visits to make sure the medicine is working.
If you will be using this medicine for a long time, your doctor should examine your eyes at regular visits to make sure this medicine does not cause unwanted effects.
Before you have any kind of surgery (including eye surgery), dental treatment, or emergency treatment , tell the medical doctor or dentist in charge and the anesthesiologist or anesthetist (the person who puts you to sleep) that you are using this medicine or have used it within the past month.
These medicines should not be used if an eye infection is present, or if the eye is wounded or injured. If redness, pain, or discharge develops, or if a foreign object becomes lodged in one or both eyes, or if you suffer a blow to the eye or eye area, notify your doctor immediately.
Avoid breathing in even small amounts of carbamate- or organophosphate-type insecticides or pesticides (for example, carbaryl [Sevin], demeton [Systox], diazinon, malathion, parathion, ronnel [Trolene], or TEPP). They may add to the effects of this medicine. Farmers, gardeners, residents of communities undergoing insecticide or pesticide spraying or dusting, workers in plants manufacturing such products, or other persons exposed to such poisons should protect themselves by wearing a mask over the nose and mouth, changing clothes frequently, and washing hands often.
Make sure your vision is clear before you drive, use machines, or do anything else that could be dangerous if you are not able to see well . This is because:
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Burning, redness, stinging, or other eye irritation; eye pain; veil or curtain appearing across part of vision
Symptoms of too much medicine being absorbed into the body
Increased sweating; loss of bladder control; muscle weakness; nausea, vomiting, diarrhea, or stomach cramps or pain; shortness of breath, tightness in chest, or wheezing; slow or irregular heartbeat; unusual tiredness or weakness; watering of mouth
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
Blurred vision or change in near or distance vision; difficulty in seeing at night or in dim light; headache or browache; twitching of eyelids; watering of eyes
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
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