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COUGH/COLD COMBINATIONS (Systemic)

Some commonly used brand names are:

In the U.S.—

  • Alka-Seltzer Plus Cold and Cough 21
  • Alka-Seltzer Plus Cold and Cough Medicine Liqui-Gels 34
  • Alka-Seltzer Plus Night-Time Cold Liqui-Gels 35
  • Ami-Tex LA 69
  • Anatuss LA 70
  • Benylin Expectorant 54
  • Bromfed-DM 17
  • Broncholate 68
  • Carbinoxamine Compound-Drops 18
  • Cardec DM 18
  • Children"s Tylenol Cold Plus Cough Multi Symptom 34
  • Co-Apap 34
  • Codeprex 1
  • Comtrex Daytime Maximum Strength Cold, Cough, and Flu Relief 60
  • Comtrex Daytime Maximum Strength Cold and Flu Relief 60
  • Comtrex Multi-Symptom Maximum Strength Non-Drowsy Caplets 60
  • Comtrex Nighttime Maximum Strength Cold and Flu Relief 34
  • Congestac Caplets 70
  • Contac Cold/Flu Day Caplets 60
  • Contac Severe Cold and Flu Caplets 34
  • Co-Tuss V 56
  • Deconsal II 70
  • Despec 69
  • Despec-SR Caplets 70
  • Donatussin 42
  • Donatussin DC 62
  • Duratuss 70
  • Duratuss HD 65
  • ED-TLC 22
  • ED Tuss HC 22
  • Endagen-HD 22
  • Endal Expectorant 61
  • Entex LA 69
  • Father John"s Medicine Plus 43
  • Genatuss DM 54
  • GP-500 70
  • Guaifed 70
  • Guaifenex PSE 60 70
  • Guaifenex PSE 120 70
  • GuaiMAX-D 70
  • Guai-Vent/PSE 70
  • Guiatuss A.C. 53
  • Guiatuss CF 64
  • Guiatuss DAC 63
  • Guiatuss PE 70
  • Histinex HC 22
  • Histinex PV 25
  • Hycodan 51
  • Hycomine Compound 32
  • Hydropane 51
  • Iobid DM 54
  • Iodal HD 22
  • Iosal II 70
  • Iotussin HC 22
  • Kolephrin/DM Cough and Cold Medication 34
  • Kolephrin GG/DM 54
  • Kwelcof Liquid 56
  • Mapap Cold Formula 34
  • Marcof Expectorant 57
  • Nalex DH 58
  • Novahistine DH Liquid 23
  • Nucofed Expectorant 63
  • Nucofed Pediatric Expectorant 63
  • Nucotuss Expectorant 63
  • Nucotuss Pediatric Expectorant 63
  • Nytcold Medicine 35
  • Nytime Cold Medicine Liquid 35
  • Ornex Severe Cold No Drowsiness Caplets 60
  • PanMist-JR 70
  • PediaCare Cough-Cold 24
  • PediaCare Night Rest Cough-Cold Liquid 24
  • Pediacof Cough 41
  • Phanatuss 54
  • Phenameth VC 14
  • Phenergan with Codeine 5
  • Phenergan with Dextromethorphan 6
  • Phenergan VC with Codeine 29
  • Pneumotussin HC 56
  • Poly-Histine 15
  • Primatuss Cough Mixture 4 2
  • Primatuss Cough Mixture 4D 64
  • Profen II 70
  • Promethazine DM 6
  • Promethazine VC w/Codeine 29
  • Prometh VC with Codeine 29
  • Protuss-D 66
  • Pseudo-Car DM 18
  • P-V-Tussin 26
  • Quelidrine Cough 39
  • Rentamine Pediatric 20
  • Rescon-DM 24
  • Rescon-GG 69
  • Respa-1st 70
  • Respa-DM 54
  • Respaire-60 SR 70
  • Respaire-120 SR 70
  • Rhinosyn-DM 24
  • Rhinosyn-DMX Expectorant 54
  • Rhinosyn-X 64
  • Robafen AC Cough 53
  • Robafen DAC 63
  • Robafen DM 54
  • Robitussin A-C 53
  • Robitussin Cold and Cough Liqui-Gels 64
  • Robitussin Cold, Cough and Flu Liqui-Gels 67
  • Robitussin-DAC 63
  • Robitussin-DM 54
  • Robitussin Night Relief 36
  • Robitussin Night-Time Cold Formula 35
  • Robitussin-PE 70
  • Robitussin Pediatric Cough and Cold 59
  • Robitussin Severe Congestion Liqui-Gels 70
  • Rondamine-DM Drops 18
  • Rondec-DM 18
  • Rondec-DM Drops 18
  • Ru-Tuss DE 70
  • Ru-Tuss Expectorant 64
  • Ryna-C Liquid 23
  • Ryna-CX Liquid 63
  • Rynatuss 20
  • Rynatuss Pediatric 20
  • Safe Tussin 30 54
  • Scot-Tussin DM 2
  • Scot-Tussin Senior Clear 54
  • Sildec-DM 17
  • Silexin Cough 54
  • Siltussin DM 54
  • Sinufed Timecelles 70
  • Sinutab Non-Drying No Drowsiness Liquid Caps 70
  • Stamoist E 70
  • Statuss Green 19
  • S-T Forte 2 3
  • Sudafed Children"s Non-Drowsy Cold and Cough 64
  • Sudafed Cold and Cough Liquid Caps 67
  • Sudafed Children"s Cold and Cough 64
  • Sudal 60/500 70
  • Syracol CF 54
  • TheraFlu Flu, Cold and Cough Medicine 34
  • TheraFlu Maximum Strength Non-Drowsy Formula Flu, Cold and Cough Medicine 60
  • TheraFlu Maximum Strength Non-Drowsy Formula Flu, Cold and Cough Medicine Caplets 60
  • TheraFlu Nighttime Maximum Strength Flu, Cold and Cough 34
  • Tolu-Sed DM 54
  • Touro DM 54
  • Touro LA Caplets 70
  • Triacin C Cough 30
  • Triafed w/Codeine 30
  • Triaminic AM Non-Drowsy Cough and Decongestant 59
  • Triaminic Night Time 24
  • Triaminic Sore Throat Formula 60
  • Tri-Tannate Plus Pediatric 20
  • Tussafed 18
  • Tussafed Drops 18
  • Tussar DM 21
  • Tussigon 51
  • Tussionex Pennkinetic 3
  • Tussi-Organidin DM NR Liquid 54
  • Tussi-Organidin DM-S NR Liquid 54
  • Tussi-Organidin NR Liquid 53
  • Tussi-Organidin-S NR Liquid 53
  • Tussirex 47
  • Tuss-LA 70
  • Tusso-DM 55
  • Tylenol Cold and Flu No Drowsiness Powder 60
  • Tylenol Cold Medication 34
  • Tylenol Cold Medication Caplets 34
  • Tylenol Cold Medication, Non-Drowsy Caplets 60
  • Tylenol Cold Medication, Non-Drowsy Gelcaps 60
  • Tylenol Cold Multi-Symptom 34
  • Tylenol Maximum Strength Flu Gelcaps 60
  • Tylenol Multi-Symptom Cough 60
  • Uni-tussin DM 54
  • Vanex-HD 22
  • V-Dec-M 70
  • Versacaps 70
  • Vicks Children"s NyQuil Cold/Cough Relief 24
  • Vicks 44 Cough and Cold Relief Non-Drowsy LiquiCaps 59
  • Vicks 44D Cough and Head Congestion 59
  • Vicks DayQuil Multi-Symptom Cold/Flu LiquiCaps 60
  • Vicks DayQuil Multi-Symptom Cold/Flu Relief 60
  • Vicks 44E Cough and Chest Congestion 54
  • Vicks 44M Cough, Cold and Flu Relief 34
  • Vicks NyQuil Hot Therapy 35
  • Vicks NyQuil Multi-Symptom Cold/Flu LiquiCaps 35
  • Vicks NyQuil Multi-Symptom Cold/Flu Relief 35
  • Vicks Pediatric 44D Cough and Head Decongestion 59
  • Vicks Children"s Cough Syrup 54
  • Vicks Pediatric 44M Multi-Symptom Cough and Cold 24
  • Vicodin Tuss 56
  • Zephrex 70
  • Zephrex-LA 70

In Canada—

  • Benylin DM-D 59
  • Benylin DM-D for Children 59
  • Benylin DM-D-E 64
  • Benylin DM-D-E Extra Strength 64
  • Benylin DM-E 54
  • Benylin DM-E Extra Strength 54
  • Benylin 4 Flu 67
  • Calmydone 27
  • Calmylin #2 59
  • Calmylin #3 64
  • Calmylin #4 10
  • Calmylin Cough and Flu 67
  • Calmylin DM-D-E Extra Strength 64
  • Calmylin Original with Codeine 9
  • Calmylin Pediatric 59
  • Cheracol 52
  • CoActifed 30
  • CoActifed Expectorant 46
  • Coristex-DH 58
  • Coristine-DH 58
  • Cotridin 30
  • Cotridin Expectorant 46
  • Dimetane Expectorant-C 37
  • Dimetane Expectorant-DC 38
  • Dimetapp-C 16
  • Entex LA 69
  • Histenol 60
  • Hycodan 51
  • Hycomine 45
  • Mersyndol with Codeine 8
  • NeoCitran DM Coughs and Colds 28
  • Novahistex DH 58
  • Novahistex DH Expectorant 62
  • Novahistine DH 58
  • Novahistine DM w/ Decongestant 59
  • Novahistine DM Expectorant w/ Decongestant 64
  • Penntuss 1
  • Pharmasave Children"s Cough Syrup 59
  • Phenergan Expectorant w/ Codeine 13
  • Robitussin A-C 11
  • Robitussin with Codeine 11
  • Robitussin Cough and Cold 64
  • Robitussin Cough and Cold Liqui-Fills 64
  • Robitussin-DM 54
  • Robitussin-PE 70
  • Robitussin Pediatric Cough and Cold 59
  • Sinutab with Codeine 33
  • Sudafed Cold and Flu Gelcaps 67
  • Sudafed Cough and Cold Extra Strength Caplets 60
  • Sudafed DM 59
  • Tanta Cough Syrup 54
  • Triaminic-DM Expectorant 44
  • Triaminic DM NightTime for Children 24
  • Tussilyn DM 24
  • Tussionex 4
  • Tylenol Children"s Cold DM Medication 34
  • Tylenol Cold and Flu 34
  • Tylenol Cold Medication Extra Strength Daytime Caplets 60
  • Tylenol Cold Medication Extra Strength Nighttime Caplets 34
  • Tylenol Cold Medication Regular Strength Daytime Caplets 60
  • Tylenol Cold Medication Regular Strength Nighttime Caplets 34
  • Tylenol Cough Extra Strength Caplets 50
  • Tylenol Cough Medication with Decongestant, Regular Strength 60
  • Tylenol Cough Medication Regular Strength 50
  • Tylenol Extra Strength Cold and Flu Medication Powder 34
  • Tylenol Junior Strength Cold DM Medication 34
  • Vicks Children"s NyQuil 24
  • Vicks DayQuil Liquicaps 60
  • Vicks Formula 44-D 59
  • Vicks Formula 44-D Pediatric 59
  • Vicks Formula 44E 54
  • Vicks Formula 44E Pediatric 54
  • Vicks Formula 44M 34
  • Vicks NyQuil 35
  • Vicks NyQuil LiquiCaps 35

Note:

For quick reference the following cough/cold combinations are numbered to match the preceding corresponding brand names.

Note:

Products containing phenylpropanolamine were removed from the U.S. and Canadian Markets in November 2000.

Antihistamine and antitussive combinations—
1. Chlorpheniramine and Codeine (klor-fen-EER-a-meenand KOE-deen)
2. Chlorpheniramine and Dextromethorphan (klor-fen-EER-a-meen and dex-troe-meth-OR-fan)
3. Chlorpheniramine and Hydrocodone (klor-fen-EER-a-meen and hye-droe-KOE-done)
4. Phenyltoloxamine and Hydrocodone (fen-ill-tole-OX-a-meen and hye-droe-KOE-done)*
5. Promethazine and Codeine (proe-METH-a-zeen and KOE-deen)
6. Promethazineand Dextromethorphan (proe-METH-a-zeenand dex-troe-meth-OR-fan)
7. Pyrilamineand Codeine (peer-ILL-a-meen and KOE-deen)
* Not commercially available in the U.S.
† Not commercially available in Canada
‡ Generic name product may be available in the U.S.
Antihistamine, antitussive, and analgesic combinations—
8. Doxylamine, Codeine, and Acetaminophen (dox-ILL-a-meen, KOE-deen, and a-seat-a-MIN-oh-fen)*
* Not commercially available in the U.S.
Antihistamine, antitussive, and expectorant combinations—
9. Diphenhydramine, Codeine, and Ammonium Chloride (dye-fen-HYE-dra-meen, KOE-deen, and a-MOE-nee-um KLOR-ide)*
10. Diphenhydramine, Dextromethorphan, and Ammonium Chloride (dye-fen-HYE-dra-meen, dex-troe-meth-OR-fan, and a-MOE-nee-um KLOR-ide)*
11. Pheniramine, Codeine, and Guaifenesin (fen-EER-a-meen, KOE-deen, and gwye-FEN-e-sin)*
12. Pheniramine, Pyrilamine, Hydrocodone, Potassium Citrate, and Ascorbic Acid (fen-EER-a-meen, peer-ILL-a-meen,hye-droe-KOE-done, poe-TAS-ee-um SI-trate, and a-SKOR-bik AS-id)
13. Promethazine, Codeine, and Potassium Guaiacolsulfonate (proe-METH-a-zeen, KOE-deen, and poe-TAS-ee-um gwye-a-kol-SUL-fon-ate)*
* Not commercially available in the U.S.
† Not commercially available in Canada
Antihistamine, and decongestant combinations—
14. Promethazine, and Phenylephrine ( proe-METH-a-zeen,and fen-ill-EF-rin )
15. Pheniramine, Pyrilamine and Phenyltoloxamine (fen-EER-a-meen, peer-ILL-a-meen, and fen-ill-tole-OX-a-meen)
† Not commercially available in Canada
Antihistamine, decongestant, and antitussive combinations—
16. Brompheniramine, Phenylephrine, and Codeine (brome-fen-EER-a-meen, fen-ill-EF-rin, and KOE-deen)
17. Brompheniramine, Pseudoephedrine, and Dextromethorphan (brome-fen-EER-a-meen, soo-doe-e-FED-rin, and dex-troe-meth-OR-fan)
18. Carbinoxamine, Pseudoephedrine, and Dextromethorphan (kar-bi-NOX-a-meen, soo-doe-e-FED-rin, and dex-troe-meth-OR-fan)
19. Chlorpheniramine, Pyrilamine, Phenylephrine, Pseudoephedrine and Hydrocodone (klor-fen-EER-a-meen, peer-ILL-a-meen,fen-ill-EF-rin, soo-doe-e-FED-rin and hye-droe-KOE-done )
20. Chlorpheniramine, Ephedrine, Phenylephrine, and Carbetapentane (klor-fen-EER-a-meen, e-FED-rin, fen-ill-EF-rin, and kar-bay-ta-PEN-tane)
21. Chlorpheniramine, Phenylephrine, and Dextromethorphan (klor-fen-EER-a-meen, fen-ill-EF-rin, and dex-troe-meth-OR-fan)
22. Chlorpheniramine, Phenylephrine, and Hydrocodone (klor-fen-EER-a-meen, fen-ill-EF-rin, and hye-droe-KOE-done)
23. Chlorpheniramine, Pseudoephedrine, and Codeine (klor-fen-EER-a-meen, soo-doe-e-FED-rin, and KOE-deen)
24. Chlorpheniramine, Pseudoephedrine, and Dextromethorphan (klor-fen-EER-a-meen, soo-doe-e-FED-rin, and dex-troe-meth-OR-fan)
25. Chlorpheniramine, Pseudoephedrine, and Hydrocodone (klor-fen-EER-a-meen, soo-doe-e-FED-rin, and hye-droe-KOE-done)
26. Chlorpheniramine, Pseudoephedrine, and Hydrocodone or Pseudoephedrine andHydrocodone (klor-fen-EER-a-meen,soo-doe-e-FED-rin, and hye-droe-KOE-done or soo-doe-e-FED-rin and hye-droe-KOE-done)
27. Doxylamine, Etafedrine, and Hydrocodone (dox-ILL-a-meen, et-a-FED-rin, and hye-droe-KOE-done)*
28. Pheniramine, Phenylephrine, and Dextromethorphan (fen-EER-a-meen, fen-ill-EF-rin, and dex-troe-meth-OR-fan)*
29. Promethazine, Phenylephrine, and Codeine (proe-METH-a-zeen, fen-ill-EF-rin, and KOE-deen)
30. Triprolidine, Pseudoephedrine, and Codeine (trye-PROE-li-deen, soo-doe-e-FED-rin, and KOE-deen)
* Not commercially available in the U.S.
† Not commercially available in Canada
Antihistamine, decongestant, antitussive, and analgesiccombinations—
31. Chlorpheniramine, Pheniramine, Pyrilamine, Phenylephrine, Hydrocodone, Salicylamide,Caffeine, and Ascorbic Acid (klor-fen-EER-a-meen,fen-EER-a-meen, peer-ILL-a-meen, fen-ill-EF-rin, hye-droe-KOE-done, sal-i-SILL-a-mide,kaf-EEN, and a-SKOR-bik AS-id)
32. Chlorpheniramine,Phenylephrine, Hydrocodone, Acetaminophen, and Caffeine (klor-fen-EER-a-meen, fen-ill-EF-rin, hye-droe-KOE-done, a-seat-a-MIN-oh-fen,and kaf-EEN)
33. Chlorpheniramine, Pseudoephedrine, Codeine, and Acetaminophen (klor-fen-EER-a-meen, soo-doe-e-FED-rin,KOE-deen, and a-seat-a-MIN-oh-fen)*
34. Chlorpheniramine,Pseudoephedrine, Dextromethorphan, and Acetaminophen (klor-fen-EER-a-meen, soo-doe-e-FED-rin, dex-troe-meth-OR-fan, and a-seat-a-MIN-oh-fen)
35. Doxylamine, Pseudoephedrine, Dextromethorphan, andAcetaminophen (dox-ILL-a-meen, soo-doe-e-FED-rin,dex-troe-meth-OR-fan, and a-seat-a-MIN-oh-fen)
36. Pyrilamine, Pseudoephedrine, Dextromethorphan, and Acetaminophen (peer-ILL-a-meen, soo-doe-e-FED-rin, dex-troe-meth-OR-fan, and a-seat-a-MIN-oh-fen)
* Not commercially available in the U.S.
† Not commercially available in Canada
Antihistamine, decongestant, antitussive, and expectorantcombinations—
37. Brompheniramine, Phenylephrine, Codeine, and Guaifenesin (brome-fen-EER-a-meen, fen-ill-EF-rin, KOE-deen, and gwye-FEN-e-sin)*
38. Brompheniramine, Phenylephrine, Hydrocodone, and Guaifenesin (brome-fen-EER-a-meen, fen-ill-EF-rin, hye-droe-KOE-done, and gwye-FEN-e-sin)*
39. Chlorpheniramine, Ephedrine, Phenylephrine, Dextromethorphan,Ammonium Chloride, and Ipecac (klor-fen-EER-a-meen,e-FED-rin, fen-ill-EF-rin, dex-troe-meth-OR-fan, a-MOE-nee-um KLOR-ide, andIP-e-kak)
40. Chlorpheniramine, Phenylephrine, Codeine and AmmoniumChloride (klor-fen-EER-a-meen, fen-ill-EF-rin,KOE-deen, and a-MOE-nee-um KLOR-ide)
41. Chlorpheniramine,Phenylephrine, Codeine, and Potassium Iodide (klor-fen-EER-a-meen, fen-ill-EF-rin, KOE-deen, and por-TAS-ee-um EYE-oh-dyed)
42. Chlorpheniramine, Phenylephrine, Dextromethorphan,and Guaifenesin (klor-fen-EER-a-meen,fen-ill-EF-rin, dex-troe-meth-OR-fan, and gwye-FEN-e-sin)
43. Chlorpheniramine, Phenylephrine, Dextromethorphan, Guaifenesin, and AmmoniumChloride (klor-fen-EER-a-meen, fen-ill-EF-rin,dex-troe-meth-OR-fan, gwye-FEN-e-sin, and a-MOE-nee-um KLOR-ide)
44. Chlorpheniramine, Pseudoephedrine, Dextromethorphan, and Guaifenesin (klor-fen-EER-a-meen, soo-doe-e-FED-rin, dex-troe-meth-OR-fan, and gwye-FEN-e-sin)*
45. Pyrilamine, Phenylephrine, Hydrocodone, and AmmoniumChloride (peer-ILL-a-meen, fen-ill-EF-rin,hye-droe-KOE-done, and a-MOE-nee-um KLOR-ide)*
46. Triprolidine, Pseudoephedrine, Codeine, and Guaifenesin (trye-PROE-li-deen, soo-doe-e-FED-rin, KOE-deen, and gwye-FEN-e-sin)*
* Not commercially available in the U.S.
† Not commercially available in Canada
Antihistamine, decongestant, antitussive, expectorant,and analgesic combinations—
47. Pheniramine, Phenylephrine, Codeine, Sodium Citrate, Sodium Salicylate, andCaffeine (fen-EER-a-meen, fen-ill-EF-rin,KOE-deen, SOE-dee-um SI-trate, SOE-dee-um sa-LI-sill-ate, and kaf-EEN)
† Not commercially available in Canada
Antihistamine, decongestant, and expectorant combinations—
48. Chlorpheniramine, Ephedrine, and Guaifenesin (klor-fen-EER-a-meen, e-FED-rin, and gwye-FEN-e-sin)
49. Promethazine, Phenylephrine, and Potassium Guaiacolsulfonate (pro-METH-a-zeen, fen-ill-EF-rin, and poe-TAS-see-um gwye-a-kol-SUL-fon-ate)*
* Not commercially available in the U.S.
† Not commercially available in Canada
Antitussive and analgesic combination—
50. Dextromethorphan and Acetaminophen (dex-troe-meth-OR-fan and a-seat-a-MIN-oh-fen)
Antitussive and anticholinergic combination—
51. Hydrocodone and Homatropine (hye-droe-KOE-done and hoe-MA-troe-peen)
‡ Generic name product may be available in the U.S.
Antitussive and expectorant combinations—
52. Codeine, Ammonium Chloride, and Guaifenesin (KOE-deen, a-MOE-nee-um KLOR-ide, and gwye-FEN-e-sin)*
53. Codeine and Guaifenesin (KOE-deen and gwye-FEN-e-sin)
54. Dextromethorphanand Guaifenesin (dex-troe-meth-OR-fanand gwye-FEN-e-sin)
55. Dextromethorphan and Iodinated Glycerol (dex-troe-meth-OR-fan and EYE-oh-di-nay-ted GLI-ser-ole)
56. Hydrocodone and Guaifenesin (hye-droe-KOE-done and gwye-FEN-e-sin)
57. Hydrocodoneand Potassium Guaiacolsulfonate (hye-droe-KOE-done and poe-TAS-see-um gwye-a-kol-SUL-fon-ate)
* Not commercially available in the U.S.
† Not commercially available in Canada
‡ Generic name product may be available in the U.S.
Decongestant and antitussive combinations—
58. Phenylephrine and Hydrocodone (fen-ill-EF-rinand hye-droe-KOE-done)
59. Pseudoephedrine and Dextromethorphan (soo-doe-e-FED-rin and dex-troe-meth-OR-fan)
Decongestant, antitussive, and analgesic combinations—
60. Pseudoephedrine, Dextromethorphan, and Acetaminophen (soo-doe-e-FED-rin, dex-troe-meth-OR-fan, and a-seat-a-MIN-oh-fen)
Decongestant, antitussive, and expectorant combinations—
61. Phenylephrine, Codeine, and Guaifenesin (fen-ill-EF-rin, KOE-deen, and gwye-FEN-e-sin)
62. Phenylephrine, Hydrocodone, and Guaifenesin (fen-ill-EF-rin, hye-droe-KOE-done, and gwye-FEN-e-sin)
63. Pseudoephedrine, Codeine, and Guaifenesin (soo-doe-e-FED-rin, KOE-deen, and gwye-FEN-e-sin)
64. Pseudoephedrine, Dextromethorphan, and Guaifenesin (soo-doe-e-FED-rin, dex-troe-meth-OR-fan, and gwye-FEN-e-sin)
65. Pseudoephedrine, Hydrocodone, and Guaifenesin (soo-doe-e-FED-rin, hye-droe-KOE-done, and gwye-FEN-e-sin)
66. Pseudoephedrine, Hydrocodone, and Potassium Guaiacolsulfonate (soo-doe-e-FED-rin, hye-droe-KOE-done, and poe-TAS-ee-um gwye-a-kol-SUL-fon-ate)
† Not commercially available in Canada
‡ Generic name product may be available in the U.S.
Decongestant, antitussive, expectorant, and analgesiccombinations—
67. Pseudoephedrine, Dextromethorphan, Guaifenesin, and Acetaminophen (soo-doe-e-FED-rin, dex-troe-meth-OR-fan, gwye-FEN-e-sin, and a-seat-a-MIN-oh-fen)
Decongestant and expectorant combinations—
68. Ephedrine and Guaifenesin (e-FED-rinand gwye-FEN-e-sin)
69. Phenylephrine and Guaifenesin (fen-ill-EF-rin and gwye-FEN-e-sin)
70. Pseudoephedrine and Guaifenesin (soo-doe-e-FED-rin and gwye-FEN-e-sin)
† Not commercially available in Canada
‡ Generic name product may be available in the U.S.

Category

  • Antihistaminic (H 1 -receptor)-antitussive—Chlorpheniramine and Dextromethorphan; Chlorpheniramine and Hydrocodone; Phenyltoloxamine and Hydrocodone; Promethazine and Codeine; Promethazine and Dextromethorphan; Pyrilamine and Codeine
  • Antihistaminic (H 1 -receptor)-antitussive-analgesic—Doxylamine, Codeine and Acetaminophen
  • Antihistaminic (H 1 -receptor)-antitussive-expectorant—Diphenhydramine, Codeine, and Ammonium Chloride; Diphenhydramine, Dextromethorphan, and Ammonium Chloride; Pheniramine, Codeine, and Guaifenesin; Pheniramine, Pyrilamine, Hydrocodone, Potassium Citrate, and Ascorbic Acid; Promethazine, Codeine, and Potassium Guaiacolsulfonate
  • Antihistaminic (H 1 -receptor) and decongestant —Promethazine and Phenylephrine; Pheniramine, Pyrilamine, and Phenyltoloxamine
  • Antihistaminic (H 1 -receptor)-decongestant-antitussive—Brompheniramine, Phenylephrine and Codeine; Brompheniramine, Pseudoephedrine, and Dextromethorphan; Carbinoxamine, Pseudoephedrine, and Dextromethorphan; Chlorpheniramine, Pyrilamine, Phenylephrine, Pseudoephedrine and Hydrocodone; Chlorpheniramine, Ephedrine, Phenylephrine, and Carbetapentane; Chlorpheniramine, Phenylephrine, and Dextromethorphan; Chlorpheniramine, Phenylephrine, and Hydrocodone; Chlorpheniramine, Pseudoephedrine, and Codeine; Chlorpheniramine, Pseudoephedrine, and Dextromethorphan; Chlorpheniramine, Pseudoephedrine, and Hydrocodone; Chlorpheniramine, Pseudoephedrine and Hydrocodone; Doxylamine, Etafedrine and Hydrocodone; Pheniramine, Phenylephrine, and Dextromethorphan; Promethazine, Phenylephrine, and Codeine; Triprolidine, Pseudoephedrine, and Codeine
  • Antihistaminic (H 1 -receptor)-decongestant-antitussive-analgesic—Chlorpheniramine, Pheniramine, Pyrilamine, Phenylephrine, Hydrocodone, Salicylamide, Caffeine, and Ascorbic Acid; Chlorpheniramine, Phenylephrine, Hydrocodone, Acetaminophen, and Caffeine; Chlorpheniramine, Pseudoephedrine, Codeine and Acetaminophen; Chlorpheniramine, Pseudoephedrine, Dextromethorphan, and Acetaminophen, ; Doxylamine, Pseudoephedrine, Dextromethorphan, and Acetaminophen; Pyrilamine, Pseudoephedrine, Dextromethorphan, and Acetaminophen
  • Antihistaminic (H 1 -receptor)-decongestant-antitussive-expectorant—Brompheniramine, Phenylephrine, Codeine and Guaifenesin; Brompheniramine, Phenylephrine, Hydrocodone and Guaifenesin; Chlorpheniramine, Ephedrine, Phenylephrine, Dextromethorphan, Ammonium Chloride, and Ipecac; Chlorpheniramine, Phenylephrine, Codeine, and Ammonium Chloride; Chlorpheniramine, Phenylephrine, Codeine, and Potassium Iodide; Chlorpheniramine, Phenylephrine, Dextromethorphan, and Guaifenesin; Chlorpheniramine, Phenylephrine, Dextromethorphan, Guaifenesin, and Ammonium Chloride; Chlorpheniramine, Pseudoephedrine, Dextromethorphan and Guaifenesin; Pyrilamine, Phenylephrine, Hydrocodone, and Ammonium Chloride; Triprolidine, Pseudoephedrine, Codeine, and Guaifenesin
  • Antihistaminic (H 1 -receptor)-decongestant-antitussive-expectorant-analgesic—Pheniramine, Phenylephrine, Codeine, Sodium Citrate, Sodium Salicylate, and Caffeine
  • Antihistaminic (H 1 -receptor)-decongestant-expectorant—Chlorpheniramine, Ephedrine, and Guaifenesin; Promethazine, Phenylephrine, and Potassium Guaiacolsulfonate
  • Antitussive-analgesic—Dextromethorphan and Acetaminophen
  • Antitussive-anticholinergic—Hydrocodone and Homatropine
  • Antitussive-expectorant—Codeine, Ammonium Chloride, and Guaifenesin; Codeine and Guaifenesin; Dextromethorphan and Guaifenesin; Dextromethorphan and Iodinated Glycerol; Hydrocodone and Guaifenesin; Hydrocodone and Potassium Guaiacolsulfonate
  • Decongestant-antitussive—Phenylephrine and Hydrocodone; Pseudoephedrine and Dextromethorphan
  • Decongestant-antitussive-analgesic—Pseudoephedrine, Dextromethorphan, and Acetaminophen
  • Decongestant-antitussive-expectorant—Phenylephrine, Codeine and Guaifenesin; Phenylephrine, Hydrocodone, and Guaifenesin; Pseudoephedrine, Codeine, and Guaifenesin; Pseudoephedrine, Dextromethorphan, and Guaifenesin; Pseudoephedrine, Hydrocodone, and Guaiacolsulfonate; Pseudoephedrine, Hydrocodone, and Guaifenesin
  • Decongestant-antitussive-expectorant-analgesic—Pseudoephedrine, Dextromethorphan, Guaifenesin, and Acetaminophen
  • Decongestant-expectorant—Ephedrine and Guaifenesin; Ephedrine and Potassium Iodide; Phenylephrine and Guaifenesin; Pseudoephedrine and Guaifenesin

Description

Cough/cold combinations are used mainly to relieve the cough due to colds, influenza, or hay fever. They are not to be used for the chronic cough that occurs with smoking, asthma, or emphysema or when there is an unusually large amount of mucus or phlegm (pronounced flem) with the cough.

Cough/cold combination products contain more than one ingredient. For example, some products may contain an antihistamine, a decongestant, and an analgesic, in addition to a medicine for coughing. If you are treating yourself, it is important to select a product that is best for your symptoms. Also, in general, it is best to buy a product that includes only those medicines you really need. If you have questions about which product to buy, check with your pharmacist.

Since different products contain ingredients that will have different precautions and side effects, it is important that you know the ingredients of the medicine you are taking. The different kinds of ingredients that may be found in cough/cold combinations include:

Antihistamines—Antihistamines are used to relieve or prevent the symptoms of hay fever and other types of allergy. They also help relieve some symptoms of the common cold, such as sneezing and runny nose. They work by preventing the effects of a substance called histamine, which is produced by the body. Some examples of antihistamines contained in these combinations are: bromodiphenhydramine (broe-moe-dye-fen-HYE-dra-meen), brompheniramine (brome-fen-EER-a-meen), carbinoxamine (kar-bi-NOX-a-meen), chlorpheniramine (klor-fen-EER-a-meen), dexchlorpheniramine (dex-klor-fen-EER-a-meen), diphenhydramine (dye-fen-HYE-dra-meen), doxylamine (dox-ILL-a-meen), phenindamine (fen-IN-da-meen), pheniramine (fen-EER-a-meen), phenyltoloxamine (fen-ill-tole-OX-a-meen), pyrilamine (peer-ILL-a-meen), promethazine (proe-METH-a-zeen), and triprolidine (trye-PROE-li-deen).

Decongestants—Decongestants, such as ephedrine (e-FED-rin), phenylephrine (fen-ill-EF-rin), and pseudoephedrine (soo-doe-e-FED-rin), produce a narrowing of blood vessels. This leads to clearing of nasal congestion. However, this effect may also increase blood pressure in patients who have high blood pressure.

Antitussives—To help relieve coughing these combinations contain either a narcotic [codeine (KOE-deen), dihydrocodeine (dye-hye-droe-KOE-deen), hydrocodone (hye-droe-KOE-done) or hydromorphone (hye-droe-MOR-fone)] or a nonnarcotic [carbetapentane (kar-bay-ta-PEN-tane), caramiphen (kar-AM-i-fen), or dextromethorphan (dex-troe-meth-OR-fan)] antitussive. These antitussives act directly on the cough center in the brain. Narcotics may become habit-forming, causing mental or physical dependence, if used for a long time. Physical dependence may lead to withdrawal side effects when you stop taking the medicine.

Expectorants—Guaifenesin (gwye-FEN-e-sin) works by loosening the mucus or phlegm in the lungs. Other ingredients added as expectorants (for example, ammonium chloride, calcium iodide, iodinated glycerol, ipecac, potassium guaiacolsulfonate, potassium iodide, and sodium citrate) have not been proven to be effective. In general, the best thing you can do to loosen mucus or phlegm is to drink plenty of water.

Analgesics—Analgesics, such as acetaminophen (a-seat-a-MIN-oh-fen), aspirin, and other salicylates [such as salicylamide (sal-i-SILL-a-mide) and sodium salicylate (SOE-dee-um sa-LI-sill-ate)] are used in these combination medicines to help relieve the aches and pain that may occur with the common cold.

The use of too much acetaminophen and salicylates at the same time may cause kidney damage or cancer of the kidney or urinary bladder. This may occur if large amounts of both medicines are taken together for a long time. However, taking the recommended amounts of combination medicines that contain both acetaminophen and a salicylate for short periods of time has not been shown to cause these unwanted effects.

Anticholinergics—Anticholinergics such as homatropine (hoe-MA-troe-peen) may help produce a drying effect in the nose and chest.

Some of these combinations are available only with your doctor"s prescription. Others are available without a prescription; however, your health care professional may have special instructions on the proper dose of the medicine for your medical condition.

Cough/cold combinations are available in the following dosage forms:

  • Antihistamine and antitussive combinations—
    • Oral
    • Chlorpheniramine and Codeine
      • Oral suspension (U.S.)
    • Chlorpheniramine and Dextromethorphan
      • Oral solution (U.S.)
    • Chlorpheniramine and Hydrocodone
      • Oral solution (U.S.)
      • Oral suspension (U.S.)
    • Phenyltoloxamine and Hydrocodone
      • Oral suspension (Canada)
      • Tablets (Canada)
    • Promethazine and Codeine
      • Oral solution (U.S.)
      • Syrup (U.S.)
    • Promethazine and Dextromethorphan
      • Oral solution (U.S.)
      • Syrup (U.S.)
    • Pyrilamine and Codeine
      • Oral solution (U.S.)
  • Antihistamine, antitussive, and analgesic combinations—
    • Oral
    • Doxylamine, Codeine, and Acetaminophen
      • Tablets (Canada)
  • Antihistamine, antitussive, and expectorant combinations—
    • Oral
    • Diphenhydramine, Codeine, and Ammonium Chloride
      • Syrup (Canada)
    • Diphenhydramine, Dextromethorphan, and Ammonium Chloride
      • Syrup (Canada)
    • Pheniramine, Codeine, and Guaifenesin
      • Syrup (Canada)
    • Pheniramine, Pyrilamine, Hydrocodone, Potassium Citrate, and Ascorbic Acid
      • Syrup (U.S.)
    • Promethazine, Codeine, and Potassium Guaiacolsulfonate
      • Syrup (Canada)
  • Antihistamine, and decongestant combinations—
    • Oral
    • Promethazine, and phenylephrine
      • Syrup (U.S.)
    • Pheniramine, Pyrilamine and Phenyltoloxamine
      • Syrup (U.S.)
  • Antihistamine, decongestant, and antitussive combinations—
    • Oral
    • Bromopheniramine, Phenylephrine, and Codeine
      • Syrup (Canada)
    • Brompheniramine, Pseudoephedrine, and Dextromethorphan
      • Syrup (U.S.)
    • Carbinoxamine, Pseudoephedrine, and Dextromethorphan
      • Oral solution (U.S.)
      • Syrup (U.S.)
    • Chlorpheniramine, Pyrilamine, Phenylephrine, Pseudoephedrine, and Hydrocodone
      • Oral solution (U.S.)
    • Chlorpheniramine, Ephedrine, Phenylephrine, and Carbetapentane
      • Oral suspension (U.S.)
      • Tablets (U.S.)
    • Chlorpheniramine, Phenylephrine, and Dextromethorphan
      • Oral solution (U.S.)
      • Syrup (U.S.)
      • Tablets (U.S.)
    • Chlorpheniramine, Phenylephrine, and Hydrocodone
      • Oral solution (U.S.)
      • Syrup (U.S.)
    • Chlorpheniramine, Pseudoephedrine, and Codeine
      • Elixir (U.S.)
      • Oral solution (U.S.)
    • Chlorpheniramine, Pseudoephedrine, and Dextromethorphan
      • Chewable tablets (U.S.)
      • Oral solution (U.S. and Canada)
      • Syrup (U.S. and Canada)
    • Chlorpheniramine, Pseudoephedrine, and Hydrocodone
      • Oral solution (U.S.)
      • Syrup (U.S.)
    • Chlorpheniramine, Pseudoephedrine, and Hydrocodone
      • Syrup (U.S.)
    • Doxylamine, Etadefrine, and Hydrocodone
      • Syrup (Canada)
    • Pheniramine, Phenylephrine, and Dextromethorphan
      • Oral solution (Canada)
    • Promethazine, Phenylephrine, and Codeine
      • Oral solution (U.S.)
      • Syrup (U.S.)
    • Triprolidine, Pseudoephedrine, and Codeine
      • Oral solution (Canada)
      • Syrup (U.S.)
      • Tablets (Canada)
  • Antihistamine, decongestant, antitussive, and analgesic combinations—
    • Oral
    • Chlorpheniramine, Pheniramine, Pyrilamine, Phenylephrine, Hydrocodone, Salicylamide, Caffeine, and Ascorbic Acid
      • Capsules (U.S.)
    • Chlorpheniramine, Phenylephrine, Hydrocodone, Acetaminophen, and Caffeine
      • Tablets (U.S.)
    • Chlorpheniramine, Pseudoephedrine, Codeine, and Acetaminophen
      • Tablets (Canada)
    • Chlorpheniramine, Pseudoephedrine, Dextromethorphan, and Acetaminophen
      • Capsules (U.S.)
      • Chewable tablets (U.S. and Canada)
      • Oral solution (U.S. and Canada)
      • Syrup (Canada)
      • Tablets (U.S. and Canada)
    • Doxylamine, Pseudoephedrine, Dextromethorphan, and Acetaminophen
      • Capsules (U.S.)
      • Oral solution (U.S.)
    • Pyrilamine, Pseudoephedrine, Dextromethorphan, and Acetaminophen
      • Oral solution (U.S.)
  • Antihistamine, decongestant, antitussive, and expectorant combinations—
    • Oral
    • Brompheniramine, Phenylephrine, Codeine, and Guaifenesin
      • Oral solution (Canada)
    • Brompheniramine, Phenylephrine, Hydrocodone, and Guaifenesin
      • Oral solution (Canada)
    • Chlorpheniramine, Ephedrine, Phenylephrine, Dextromethorphan, Ammonium Chloride, and Ipecac
      • Syrup (U.S.)
    • Chlorpheniramine, Phenylephrine, Codeine, and Ammonium Chloride
      • Oral solution (U.S.)
    • Chlorpheniramine, Phenylephrine, Codeine, and Potassium Iodide
      • Syrup (U.S.)
    • Chlorpheniramine, Phenylephrine, Dextromethorphan, and Guaifenesin
      • Syrup (U.S.)
    • Chlorpheniramine, Phenylephrine, Dextromethorphan, Guaifenesin, and Ammonium Chloride
      • Oral solution (U.S.)
    • Chlorpheniramine, Pseudoephedrine, Dextromethorphan and Guaifenesin
      • Oral solution (Canada)
    • Pyrilamine, Phenylephrine, Hydrocodone, and Ammonium Chloride
      • Syrup (Canada)
    • Triprolidine, Pseudoephedrine, Codeine, and Guaifenesin
      • Oral solution (Canada)
  • Antihistamine, decongestant, antitussive, expectorant, and analgesic combinations—
    • Oral
    • Pheniramine, Phenylephrine, Codeine, Sodium Citrate, Sodium Salicylate, and Caffeine
      • Oral solution (U.S.)
  • Antihistamine, decongestant, and expectorant combinations—
    • Oral
    • Chlorpheniramine, Ephedrine, and Guaifenesin
      • Oral solution (U.S.)
    • Promethazine, Phenylephrine, and Potassium Guaiacolsulfonate
      • Syrup (Canada)
  • Antitussive and analgesic combination—
    • Oral
    • Dextromethorphan and Acetaminophen
      • Capsules (U.S.)
      • Oral solution (U.S.)
      • Oral suspension (Canada)
      • Tablets (U.S.)
  • Antitussive and anticholinergic combination—
    • Oral
    • Hydrocodone and Homatropine (Canadian product does not contain homatropine)
      • Syrup (U.S. and Canada)
      • Tablets (U.S. and Canada)
  • Antitussive and expectorant combinations—
    • Oral
    • Codeine, Ammonium Chloride, and Guaifenesin
      • Syrup (Canada)
    • Codeine and Guaifenesin
      • Oral solution (U.S.)
      • Syrup (U.S.)
      • Tablets (U.S.)




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