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Some commonly used brand names are:
In the U.S.—
Efavirenz (eh-FAH-vih-rehnz) is used with other medicines in the treatment of the infection caused by the human immunodeficiency virus (HIV). HIV is the virus that causes acquired immune deficiency syndrome (AIDS).
Efavirenz will not cure or prevent HIV infection or AIDS; however, it helps keep HIV from reproducing and appears to slow down the destruction of the immune system. This may help delay the development of problems that usually result from AIDS or HIV disease. Efavirenz will not keep you from spreading HIV to other people. People who receive this medicine may continue to have some of the problems usually related to AIDS or HIV disease.
This medicine is available only with your doctor"s prescription, in the following dosage form(s):
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For efavirenz, the following should be considered:
Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to efavirenz. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy—Efavirenz has been shown to cause birth defects in humans. However, this medicine may be needed in serious diseases or other situations that threaten the mother"s life. A pregnancy test is recommended before starting treatment with efavirenz. In addition, it is recommended that women with the potential to become pregnant use two methods of contraception. One method of contraception should be a reliable barrier contraceptive, such as condoms, and the other method should be an oral or other hormone contraceptive, such as birth control pills. Before taking efavirenz, make sure your doctor knows if you are pregnant or if you may become pregnant.
Breast-feeding—It is not known whether efavirenz passes into the breast milk. However, patients with HIV infection should not breast-feed because of the risk of passing the virus on to the nursing infant.
Children—Children have a higher risk of developing a rash, which is sometimes severe, while taking this medicine. Your doctor may suggest that an additional medicine, an antihistamine, be taken to prevent a rash from occurring. The appearance of a rash should be reported to your doctor as soon as possible.
Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of efavirenz in the elderly with use in other age groups.
Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. It is important that you inform your health care professional of any prescription or nonprescription (OTC) medicine you are taking, especially if you are taking any of the following:
Other medical problems—The presence of other medical problems may affect the use of efavirenz. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This Medicine
Take this medicine exactly as directed by your doctor. Do not take it more often, and do not take it for a longer time than your doctor ordered. Also, do not stop taking this medicine without checking with your doctor first.
Keep taking efavirenz for the full time of treatment even if you begin to feel better. It is also important that you continue taking all other medicines for HIV infection your doctor has instructed you to take. Efavirenz will not work if it is taken alone. It must be taken with other HIV medication.
Efavirenz should be taken on an empty stomach because the amount of efavirenz absorbed into the body may be increased when taken with food, which might increase the chance of side effects.
Take efavirenz at bedtime, especially during the first 2 to 4 weeks, to lessen central nervous system (CNS) side effects that may occur with this medicine. These effects usually lessen after you have been taking this medicine for awhile.
Dosing—The dose of efavirenz will be different for different patients. Follow your doctor"s orders or the directions on the label . The following information includes only the average doses of efavirenz. If your dose is different, do not change it unless your doctor tells you to do so.
The number of capsules that you take depends on the strength of the medicine.
Missed dose—If you miss a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage—To store this medicine:
Precautions While Using This Medicine
Efavirenz may cause dizziness, difficulty in concentrating, or drowsiness. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert.
Check with your physician before taking efavirenz with alcohol or other medicines that affect the central nervous system (CNS). The use of alcohol or other medicines that affect the CNS with efavirenz may worsen the side effects of this medicine, such as dizziness, poor concentration, drowsiness, unusual dreams, and trouble in sleeping. Some examples of medicines that affect the CNS are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; medicine for depression; medicine for anxiety; prescription pain medicine or narcotics; barbiturates; medicine for attention deficit and hyperactivity disorder; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics.
Check with your doctor right away if you have serious psychiatric problems, such as severe depression, strange thoughts, or angry behavior.
Efavirenz does not decrease the risk of transmitting the HIV infection to others through sexual contact or by contamination through blood.
Women of childbearing potential should use two forms of birth control while taking this medicine, a barrier method of contraception and an oral or other hormonal method of contraception.
Check with your doctor promptly, if you develop a skin rash.
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Depression; skin rash or itching
Blood in urine; difficult or painful urination; pain in lower back and/or side
Abdominal pain; changes in vision; blistering; clumsiness or unsteadiness; confusion; convulsions (seizures); cough; dark urine; delusions; double vision; fainting; fast or pounding heartbeat; fever or chills; headache (severe and throbbing); hives; inappropriate behavior; loss of appetite; mood or mental changes (severe); muscle cramps or pain; nausea or vomiting; nerve pain; open sores; pain, tenderness, bluish color, or swelling of leg or foot; rapid weight gain; seeing, hearing, or feeling things that are not there; sense of constant movement of self or surroundings; sores, ulcers, or white spots in mouth or on lips; speech disorder; swelling and/or tenderness in upper abdominal or stomach area; swelling of hands, arms, feet, or legs; thoughts of suicide or attempts at suicide; tightness in chest; tingling, burning, or prickling sensations; tingling, burning, numbness, or pain in the hands, arms, feet, or legs; tremor; troubled breathing; unusual tiredness; weight loss; wheezing; yellow eyes or skin
Incidence not known
Actions that are out of control; attack, assault, force; continuing vomiting; delusions of persecution, mistrust, suspiciousness, and/or combativeness; difficult or labored breathing; early appearance of redness or swelling of the skin; general feeling of tiredness or weakness; irritability; late appearance of rash with or without weeping blisters that become crusted, especially in sun-exposed areas of skin, may extend to unexposed areas; light-colored stools; nervousness; neurosis; shortness of breath; stomach pain; talking, feeling, and acting with excitement
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
Diarrhea; dizziness; drowsiness; fatigue; headache; increased sweating; poor concentration; trouble in sleeping
Less common or rare
Abnormally decreased sensitivity, particularly to touch; agitation or anxiety; belching; change in sense of taste or smell; dry mouth; excessive gas; false sense of well-being; flaking and falling off of skin; flushing; general feeling of discomfort; heartburn; indigestion; joint pain; lack of feeling or emotion; loss of hair; loss of memory; loss of sense of reality; mood changes; nervousness; pain; painful, red, hot or irritated hair follicles; ringing in the ears; stomach discomfort; unusual dreams; weakness
Incidence not known
Difficulty having a bowel movement (stool); discoloration of fingernails or toenails; large amount of triglyceride in the blood; malabsorption; muscular pain, tenderness, wasting or weakness; redistribution/accumulation of body fat; swelling of the breasts or breast soreness in both females and males
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
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