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Some commonly used brand names are:
In the U.S.—
Ibandronate (i-BAN-dro-nate) is used to treat or prevent osteoporosis (thinning of the bone) in women after menopause.
This medicine is available only with your doctor"s prescription, in the following dosage forms:
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For ibandronate, the following should be considered:
Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to ibandronate. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy—Ibandronate has not been studied in pregnant women. However, studies in animals have shown that ibandronate may causes birth defects and other pregnancy problems. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.
Breast-feeding—It is not known whether ibandronate passes into breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers who are taking this medicine and who wish to breast-feed should discuss this with their doctor.
Children—Studies on this medicine have been done only in adult patients and there is no specific information comparing use of ibandronate in children with use in other age groups.
Older adults—This medicine has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults.
Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary.
Tell your health care professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Other medical problems—The presence of other medical problems may affect the use of ibandronate. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This Medicine
Make certain your health care professional knows if you are on any special diet, such as a low-sodium or low-sugar diet. Your doctor may recommend that you eat a balanced diet with an adequate amount of calcium and vitamin D (found in milk or other dairy products).
Take ibandronate with a full glass (6 to 8 ounces) of plain water on an empty stomach . It should be taken in the morning at least 60 minutes before any food, beverage, or other medicines. Food and beverages, such as mineral water, coffee, tea, or juice, will decrease the amount of ibandronate absorbed by the body. Waiting longer than 60 minutes will allow more of the drug to be absorbed. Medicines such as antacids, calcium or vitamin supplements will also decrease the absorption of ibandronate.
Do not lie down for 60 minutes after taking ibandronate . This will help ibandronate reach your stomach faster. It will also help prevent irritation to your esophagus.
Your doctor may recommend that you eat a balanced diet with an adequate amount of calcium and vitamin D (found in milk or other dairy products). However, do not take any food, beverages, or calcium or vitamin supplements within 60 minutes or longer of taking ibandronate. To do so may keep this medicine from working properly.
For the injection : You will receive this medicine from a healthcare professional every 3 months. You should not receive this injection more often than every 3 months.
Dosing—The dose of ibandronate will be different for different patients. Follow your doctor"s orders or the directions on the label . The following information includes only the average doses of ibandronate. If your dose is different, do not change it unless your doctor tells you to do so.
Missed dose—For 2.5 mg tablet once a day—If you miss a dose of this medicine, do not take it later in the day. Resume your schedule the next morning. Do not double doses.
For 150 mg tablet once a month—If you miss a dose of this medicine and your next scheduled dose is more than 7 days away, take one tablet in the morning. Resume your schedule the next month. If you miss a dose of this medicine and your next scheduled dose is only 1 to 7 days away, you must wait until your next scheduled dose. Resume your schedule the next month. Do not double doses. Do not take more than two tablets within the same week.
For injection every 3 months—If you miss a scheduled appointment to receive a dose of this medicine, it should be rescheduled as soon as possible. Then, resume the schedule of every 3 months from the date of the last injection.
Storage—To store this medicine:
Precautions While Using This Medicine
It is important that your doctor check your progress at regular visits to make sure this medicine is working properly and watch for unwanted effects.
Tell your doctor right away if you develop symptoms of your esophagus being irritated such as new or worsening difficulty swallowing, pain on swallowing, pain behind your breast bone, or heartburn.
Importance of not lying down for at least 60 minutes after taking ibandronate.
Importance of taking ibandronate at least 60 minutes before first food, beverage, or medication of the day.
Importance of taking antacids, calcium supplements, or other products containing aluminum, iron, or magnesium at least 60 minutes after ibandronate.
Use of aspirin or nonsteroidal anti-inflammatory drugs (e.g. Aleve, Motrin) may increase your risk for stomach problems.
Do not chew or suck on the tablet. Swallow whole with 6 to 8 ounces of plain water.
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Bladder pain; bloody or cloudy urine; chest pain; cough producing mucus; difficulty breathing; difficult, burning, or painful urination; fever or chills; frequent urge to urinate; lower back or side pain; nervousness; pounding in the ears; shortness of breath; slow or fast heartbeat; sneezing; sore throat; tightness in chest; wheezing
Bloody or cloudy urine; body aches or pain; congestion; difficult, burning, or painful urination; difficulty swallowing; dizziness; dryness of throat; fast heartbeat; frequent urge to urinate; hives; hoarseness; itching; large amount of cholesterol in the blood; numbness; puffiness or swelling of the eyelids or around the eyes, face, lips or tongue; runny nose; skin rash; tender, swollen glands in neck; tingling; trouble in swallowing; unusual tiredness or weakness; voice changes
Blurred vision or other change in vision; bone, joint, and/or muscle pain, severe and occasionally incapacitating; eye redness; eye tenderness; heavy jaw feeling; loosening of a tooth; pain, swelling, or numbness in the mouth or jaw; sensitivity to light; severe eye pain; tearing
Symptoms of overdose
Get emergency help immediately if any of the following symptoms of overdose occur
Abdominal cramps; acid or sour stomach; belching; bone pain; burning feeling in chest or stomach; chest pain; confusion; convulsions; difficulty in breathing; difficulty in swallowing; heartburn; indigestion; irregular heartbeats; loss of appetite; mood or mental changes; muscle cramps in hands, arms, feet, legs, or face; numbness and tingling around the mouth, fingertips, or feet; pain or burning in throat; shortness of breath; stomach discomfort upset or pain; sores, ulcers; tenderness in stomach area; tremor; ulcer; unusual tiredness or weakness; upset stomach; vomiting; white spots on lips or tongue or inside the mouth
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome.
Acid or sour stomach; belching; diarrhea; ear congestion; headache; heartburn; indigestion; loss of voice; pain in extremity (arms and legs); stomach discomfort, upset or pain
Abdominal or stomach pain; bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hive, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at site; cough; difficulty having a bowel movement [stool]; difficulty in moving; discouragement; feeling of constant movement of self or surroundings; feeling sad or empty; general feeling of discomfort or illness; irritability; joint pain; lack or appetite; lack or loss of strength; loss of interest or pleasure; lightheadedness; muscle aches and pain; muscle pain or stiffness; nausea; pain, swelling, or redness in joints; sensation of spinning; shivering; sore throat; stuffy or runny nose; sweating; tiredness; tooth disorder; trouble concentrating; trouble sleeping; vomiting; weakness
Sleeplessness; unable to sleep
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
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