ibuprofen and oxycodone

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Combunox, |ibuprofen and oxycodone

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ibuprofen and oxycodone

Generic Name: ibuprofen and oxycodone (eye byoo PROE fen and ox i KOE done)
Brand Names: Combunox

What is ibuprofen and oxycodone?

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). It relieves pain and decreases inflammation. Oxycodone (related to codeine) is in a class of drugs called narcotic analgesics. It is a pain reliever.

Ibuprofen and oxycodone are used together for the short-term (less than 7 days) treatment of pain.

Ibuprofen and oxycodone may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about ibuprofen and oxycodone?

In rare cases, the use of ibuprofen has caused serious side effects. Contact your doctor immediately if you experience black, bloody or tarry stools; abdominal pain; bloody vomit; blurred vision or other visual problems; rash; sudden weight gain; or swelling.

Do not take other prescription or over-the-counter medications that contain ibuprofen (Motrin, Advil, others) while taking ibuprofen and oxycodone without first talking to your doctor.

Never take more ibuprofen and oxycodone than is prescribed for you. If your pain is not being adequately treated, talk to your doctor.

Use caution when driving, operating machinery, or performing other hazardous activities. Ibuprofen and oxycodone may cause drowsiness or dizziness. If you experience drowsiness or dizziness, avoid these activities. Do not drink alcohol while taking ibuprofen and oxycodone. Alcohol may increase drowsiness or dizziness. Alcohol may also increase the risk of dangerous stomach bleeding while taking this medication. Ibuprofen and oxycodone may cause constipation. Drink plenty of water (six to eight full glasses a day) to lessen this side effect. Increasing the amount of fiber in your diet may also help to alleviate constipation.

What should I discuss with my healthcare provider before taking ibuprofen and oxycodone?

Oxycodone is habit forming and should only be used under close supervision if you have an alcohol or drug addiction.

Before taking this medication, tell your doctor if you have

  • kidney disease;
  • liver disease;
  • asthma;

  • urinary retention or an enlarged prostate;

  • hypothyroidism;

  • gallbladder disease;

  • a head injury;

  • Addison"s disease;

  • an allergy to aspirin or any other NSAIDs;

  • an ulcer or bleeding in the stomach;

  • a bleeding or blood clotting disorder,

  • high blood pressure, heart disease, or fluid retention; or

  • a history of drug or alcohol addiction.

You may not be able to take ibuprofen and oxycodone, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

This drug combination is in the FDA pregnancy category C. This means that it is not known whether it will harm an unborn baby. Ibuprofen should not be taken in late pregnancy because it may affect the baby"s heart. Do not take this medication without first talking to your doctor if you are pregnant. It is not known whether ibuprofen and oxycodone passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take ibuprofen and oxycodone?

Take ibuprofen and oxycodone exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. Ibuprofen and oxycodone can be taken with food or milk to decrease stomach upset.

Never take more ibuprofen and oxycodone than is prescribed for you. If your pain is not being adequately treated, talk to your doctor.

Ibuprofen and oxycodone may cause constipation. Drink plenty of water (six to eight full glasses a day) to lessen this side effect. Increasing the amount of fiber in your diet may also help to alleviate constipation. Do not share this medication with anyone else. Store ibuprofen and oxycodone at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Wait the prescribed amount of time before taking your next dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a ibuprofen and oxycodone overdose include slow breathing, dizziness, drowsiness, ringing in the ears, blurred vision, confusion, coma, and death.

What should I avoid while taking ibuprofen and oxycodone?

Use caution when driving, operating machinery, or performing other hazardous activities. Ibuprofen and oxycodone may cause drowsiness or dizziness. If you experience drowsiness or dizziness, avoid these activities. Do not drink alcohol while taking ibuprofen and oxycodone. Alcohol may increase drowsiness or dizziness. Alcohol may also increase the risk of stomach bleeding while taking this medication.

Do not take other prescription or over-the-counter medications that contain ibuprofen (Motrin, Advil, others) while taking ibuprofen and oxycodone without first talking to your doctor.

Drowsiness or dizziness caused by ibuprofen and oxycodone may be increased by the effects of other drugs that cause drowsiness including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, muscle relaxants, and many others. Tell your doctor about all medicines that you are taking and do not take any medicine without first talking to your doctor.

Ibuprofen and oxycodone side effects

If you experience any of the following serious side effects, stop taking ibuprofen and oxycodone and seek emergency medical attention or contact your doctor immediately:
  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

  • slow or weak breathing;

  • yellowing of the skin or eyes;

  • unusual fatigue, bleeding, or bruising;

  • abdominal cramping, indigestion, or heartburn;

  • black, bloody, or tarry stools;

  • bloody vomit;

  • decreased hearing or ringing in the ears;

  • blurred vision or other visual problems; or

  • sudden weight gain (fluid retention).

Other, less serious side effects may be more likely to occur. Continue to take ibuprofen and oxycodone and talk to your doctor if you experience

  • constipation;

  • dry mouth, nausea, or decreased appetite;

  • dizziness, tiredness, or lightheadedness;

  • muscle twitches;

  • sweating;

  • itching; or

  • decreased urination.

Ibuprofen and oxycodone is habit forming. Dependence may develop if it is taken for a prolonged period of time and withdrawal effects may occur if it is stopped suddenly after prolonged treatment.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect ibuprofen and oxycodone?

Before taking ibuprofen and oxycodone, tell your doctor if you are taking any of the following medicines:

  • another nonsteroidal anti-inflammatory drug (NSAID) such as ketoprofen (Orudis, Orudis KT, Oruvail), naproxen (Naprosyn, Aleve, Anaprox), diclofenac (Voltaren, Cataflam), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), indomethacin (Indocin), ketorolac (Toradol), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), or tolmetin (Tolectin);
  • aspirin or another salicylate (form of aspirin) such as salsalate (Disalcid), choline salicylate, and magnesium salicylate;

  • a diuretic (water pill) such as hydrochlorothiazide (HCTZ, HydroDiuril, others), chlorothiazide (Diuril, others), chlorthalidone (Thalitone), bumetanide (Bumex), ethacrynic acid (Edecrin), furosemide (Lasix), spironolactone (Aldactone), and amiloride (Midamor);

  • an anticoagulant such as warfarin (Coumadin); or

  • lithium (Eskalith, Lithobid, others).

You may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Drowsiness or dizziness caused by ibuprofen and oxycodone may be increased by the effects of other drugs that cause drowsiness including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, muscle relaxants, and many others. Tell your doctor about all medicines that you are taking and do not take any medicine without first talking to your doctor.

Drugs other than those listed here may also interact with ibuprofen and oxycodone. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Where can I get more information?

  • Your pharmacist has additional information about ibuprofen and oxycodone written for health professionals that you may read.

What does my medication look like?

Ibuprofen and oxycodone is available with a prescription under the brand name Combonux. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Combonux 400 mg ibuprofen/5 mg oxycodone-white, film coated tablets

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 1.01. Revision Date: 12/16/04 3:50:52 PM.




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