Naltrexone

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|Naltrexone

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Naltrexone


Generic Name: Naltrexone (nal-TREX-ohn)
Brand Name: Revia

Naltrexone can cause liver problems when given in large doses. Stop using Naltrexone and seek immediate medical help if symptoms of liver problems develop, such as abdominal or stomach pain for more than a few days, white bowel movements, yellowing of the eyes or skin, or dark urine. Naltrexone must not be used in patients who already have liver problems (eg, hepatitis, liver failure).


Naltrexone is used for:

Treating alcoholism and narcotic (opioid) addiction in adults, as part of a complete treatment program. It may also be used to treat other conditions as determined by your doctor.

Naltrexone is a narcotic antagonist. It is thought to work by blocking the effects of injectable opioids (eg, heroin, narcotic pain relievers). It has also been shown to decrease alcohol consumption.

Do NOT use Naltrexone if:

  • you are allergic to any ingredient in Naltrexone
  • you are taking narcotic medications for pain, are dependent on narcotics, are experiencing withdrawal symptoms from narcotics, have failed the challenge test with Naltrexone , or have tested positive for narcotics
  • you have hepatitis, liver failure, or liver disease

Contact your doctor or health care provider right away if any of these apply to you.

Before using Naltrexone :

Some medical conditions may interact with Naltrexone . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have kidney or liver problems, or a history of suicidal thoughts or behavior with or without depression

Some MEDICINES MAY INTERACT with Naltrexone . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Narcotic analgesics (eg, codeine), narcotic cough/cold medicines, or medicines used for diarrhea because effectiveness may be decreased by Naltrexone . Withdrawal symptoms may occur if you are physically dependent on opioid medicines.
  • Thioridazine because side effects such as sleepiness and sluggishness may occur

This may not be a complete list of all interactions that may occur. Ask your health care provider if Naltrexone may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Naltrexone :

Use Naltrexone as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Naltrexone may be taken with or without food.
  • Naltrexone should not be taken until the naltrexone challenge test is negative.
  • Before taking Naltrexone , you must be willing to take Naltrexone to help with alcohol dependence, you must be free of substance abuse for 7 to 10 days, you must not have any severe or active liver or kidney problems, and you must not have any other medical problems or conditions that make taking Naltrexone inadvisable.
  • If you miss a dose of Naltrexone and you are taking 1 dose daily, do no try to make up the missed dose by doubling the dose the next day. Take the next scheduled dose and consult your doctor.

Ask your health care provider any questions you may have about how to use Naltrexone .

Important safety information:

  • Naltrexone may cause dizziness or drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Naltrexone . Using Naltrexone alone, with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
  • Carry identification to alert health care providers that you are taking Naltrexone . You can get a medication card from your doctor to use for this purpose.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Naltrexone .
  • Contact your health care provider at once if any of the following signs or symptoms of hepatitis occur while taking Naltrexone : stomach pain lasting more than a few days; white bowel movements; dark urine; yellowing of the skin or eyes.
  • Do not use narcotics while taking Naltrexone , including opioid-containing medicines (eg, cough and cold products, pain relievers, heroin). Naltrexone may increase your sensitivity to narcotics. Therefore, even very low doses may cause coma or be life-threatening.
  • Before you have any medical or dental surgery or emergency treatments, tell the doctor or dentist that you are taking Naltrexone .
  • LAB TESTS, including liver function, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Naltrexone with extreme caution in CHILDREN younger than 18 years of age. Safety and effectiveness in this age group have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Naltrexone during pregnancy. It is unknown if Naltrexone is excreted in breast milk. If you are or will be breast-feeding while you are using Naltrexone , check with your doctor or pharmacist to discuss the risks to your baby.

If you are addicted to narcotics and are given Naltrexone , you may experience WITHDRAWAL symptoms including anxiety; diarrhea; fever, runny nose or sneezing; goose bumps and abnormal skin sensations; nausea; vomiting; pain; rigid muscles; rapid heartbeat; seeing, hearing, or feeling things that are not there; shivering or tremors; sweating; and trouble sleeping.

Possible side effects of Naltrexone :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; appetite loss; chills; constipation; delayed ejaculation; diarrhea; dizziness; drowsiness; feeling down; headache; increased energy; increased thirst; irritability; joint and muscle pain; low energy; nausea; nervousness; sleeplessness; stomach pain/cramps; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abdominal or stomach pain; cramping; dark urine; depression; suicidal thoughts or behaviors; unusual tiredness or weakness; vomiting; white bowel movements; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately.

Proper storage of Naltrexone :

Store this medicine at room temperature, 59 to 86 degrees F (15 to 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Naltrexone out of the reach of children and away from pets.

General information:

  • If you have any questions about Naltrexone , please talk with your doctor, pharmacist, or other health care provider.
  • Naltrexone is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Naltrexone . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition 06.4.1.002
Copyright © 2006 Wolters Kluwer Health, Inc.




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