palifermin
 Palifermin

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Kepivance, |palifermin Palifermin

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palifermin

Generic Name: palifermin (pal E fair men)
Brand Names: Kepivance

What is palifermin?

Palifermin is a human keratinocyte growth factor (KGF) produced by recombinant DNA technology.

Palifermin is used to reduce the chance of developing sores and ulcers in the mouth and to shorten the time with sores or ulcers in patients with blood cancers who receive high doses of chemotherapy and radiation therapy before bone marrow transplants.

Palifermin may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about palifermin?

Palifermin is given as an I .V. (in the vein) infusion for three days before you get chemotherapy and then three days after. Palifermin should not be given to you within 24 hours of your chemotherapy treatment.

If you experience any of the following serious side effects from palifermin, seek emergency medical attention or contact your doctor immediately:

  • fever;

  • breathing problems;

  • skin and mucus membrane side effects such as rash, redness, swelling, itching, unusual sensations in the mouth, tongue color change, tongue thickening and changes in taste.

What should I discuss with my healthcare provider before receiving palifermin?

Palifermin is given as an I .V. (in the vein) infusion for three days before you get chemotherapy and then three days after. Palifermin should not be given to you within 24 hours of your chemotherapy treatment.

Before you start receiving palifermin, tell your health care professional if you are allergic to other products made from E. coli proteins.

Palifermin can cause possible tumor growth if it is used for nonblood related cancers. Talk to your doctor if you have any questions.

If you experience any of the following serious side effects from palifermin, seek emergency medical attention or contact your doctor immediately:

  • fever;

  • breathing problems;

  • skin and mucus membrane side effects such as rash, redness, swelling, itching, unusual sensations in the mouth, tongue color change, tongue thickening and changes in taste.

Other common side effects include:

  • swelling;

  • pain;

  • joint pain;

  • increases in blood pancreas enzymes;

  • increased blood pressure; or

  • protein in the urine.

Palifermin has not yet been shown to be safe and effective in patients being treated for forms of cancer other than leukemia or lymphoma.

Palifermin is in the FDA pregnancy category C. This means that it is not known whether palifermin will be harmful to an unborn baby. Do not use palifermin without first talking to your doctor if you are pregnant or could become pregnant during treatment. Discuss with your doctor the appropriate use of birth control during treatment with palifermin if necessary. It is not known whether palifermin passes into breast milk. Do not take palifermin without first talking to your doctor if you are breast feeding a baby.

How should I use palifermin?

Palifermin is administered as an intravenous (into the vein) infusion. Most often, palifermin is administered in a hospital or clinic setting. If you are administering palifermin at home, your healthcare provider will give you detailed instructions regarding preparation, administration, and storage of the medication.

Your doctor will determine the correct amount and frequency of treatment with palifermin Talk to your doctor if you have any questions or concerns regarding the treatment schedule.

Palifermin vials should be stored in the refrigerator. Palifermin vials should be protected from light. Store palifermin in the original carton until it is used. Do not freeze palifermin products.

What happens if I miss a dose?

Contact your doctor if you miss a dose of palifermin.

What happens if I overdose?

If an overdose of palifermin is suspected, seek emergency medical attention or contact your healthcare provider immediately.

Symptoms of a palifermin overdose are not well known but may include headache.

What should I avoid while using palifermin?

Palifermin is given as an I .V. (in the vein) infusion for three days before you get chemotherapy and then three days after. Palifermin should not be given to you within 24 hours of your chemotherapy treatment.

Palifermin side effects

If you experience any of the following serious side effects from palifermin, seek emergency medical attention or contact your doctor immediately:

  • fever;

  • breathing problems;

  • skin and mucus membrane side effects such as rash, redness, swelling, itching, unusual sensations in the mouth, tongue color change, tongue thickening and changes in taste.

Other common side effects include:

  • swelling;

  • pain;

  • joint pain;

  • increases in blood pancreas enzymes;

  • increased blood pressure; or

  • protein in the urine.

Side effects other than those listed here have also been reported. Discuss with your doctor any side effect that occurs during treatment with palifermin.

What other drugs will affect palifermin?

Palifermin can interact with heparin. If heparin is used to maintain your IV, your IV must be flushed with saline before and after palifermin.

Other medications may interact with palifermin. Talk to your doctor and pharmacist before taking any other prescription or over-the-counter medicines, including vitamins, minerals, and herbal products, during treatment with palifermin.

Where can I get more information?

  • Your healthcare provider may have additional information about palifermin that you may read.

What does my medication look like?

Palifermin injection is available with a prescription under the brand name Kepivance. Other brand or generic formulations may also be available. Ask your healthcare provider or pharmacist any questions you have about this medication, especially if it is new to you.

  • Kepivance 6.25mg vials.

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 1.01. Revision Date: 8/11/05 1:57:38 PM.




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