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QUINACRINE (Systemic) *†
Other commonly used names are:Mepacrine
Quinacrine (KWIN-a-kreen)is used to treat giardiasis((jee-ar-DYE-a-siss)), a protozoal infection of the intestinal tract, and certain types of lupus erythematosus((e-ri-thi-ma-TOE-sus)), an inflammatory disease that affects the joints, tendons, and other connective tissues and organs. Quinacrine may be injected into the space surrounding the lungs to prevent reoccurrence of pneumothorax. This medicine also may be used for other conditions as determined by your doctor.
Quinacrine is available only with your doctor"s prescription.
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For Quinacrine], the following should be considered:
Allergies- Tell your doctor if you have ever had any unusual or allergic reaction to quinacrine. Also tell your doctor and pharmacist if you are allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy- Quinacrine crosses the placenta, and its use in pregnant women is generally not recommended.
Breast-feeding- Quinacrine passes into breast milk. However, quinacrine has not been reported to cause problems in nursing babies.
Children- Children tolerate the oral dosage form of quinacrine less well than do adults, and it may cause vomiting in children due to its bitter taste.
Older adults- Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of quinacrine in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.
Other medicines- Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking quinacrine, it is especially important that your doctor and pharmacist know if you are taking any of the following:
Other medical problems- The presence of other medical problems may affect the use of quinacrine. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This Medicine
Quinacrine is best taken after meals with a full glass (8 ounces) of water, tea, or fruit juice, unless directed by your doctor.
For patients unable to swallow tablets or capsules or unable to tolerate bitter taste :
For patients taking quinacrine for giardiasis:
Dosing- The dose of Quinacrine will be different for different patients. Follow your doctor"s orders or the directions on the label . The following information includes only the average doses of quinacrine. If your dose is different, do not change it unless your doctor tells you to do so.
Missed dose- If you do miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage- To store this medicine:
Precautions While Using This Medicine
It is very important that your doctor check your progress at different times. This is to check whether or not the infection is cleared up completely.
If your symptoms do not improve within a few days or if they become worse, check with your doctor.
Quinacrine may cause some people to become dizzy. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert . If this reaction is especially bothersome, check with your doctor.
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. When this medicine is used for a short time, side effects are not generally serious. However, if this medicine is used for a long time and/or in high doses, other more serious side effects may occur.
Check with your doctor immediately if any of the following side effects occur:
Black, tarry stools; blood in urine or stools; cough or hoarseness accompanied by a fever or chills; pinpoint red spots on skin; skin rash, redness, itching or peeling; unusual bleeding or bruising
Vision changes; yellow discoloration of eyes and skin
Symptoms of Overdose
Get emergency help immediately if any of the following symptoms of overdose occur
Convulsions (seizures); fainting; irregular heartbeat
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome.
Abdominal or stomach cramps; diarrhea; dizziness; fever; headache; loss of appetite; nausea or vomiting
Quinacrine is a dye-like medicine and commonly causes yellow discoloration of the skin and urine, and darkening of the fingernails and toenails . These side effects are only temporary and will go away when you stop taking this medicine. However, if you notice yellow discoloration of your eyes, check with your doctor as soon as possible because medical attention may be required.
Chest pain (for injection form only)
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your doctor.
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