Rasburicase

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Rasburicase


Generic Name: Rasburicase (ras-BYOOR-i-kayse)
Brand Name: Elitek

Rasburicase can cause a severe allergic reaction. If you develop new symptoms such as chest pain, trouble breathing, severe dizziness, a rash, or hives, stop using Rasburicase and seek immediate medical attention. Do not restart Rasburicase if a severe allergic reaction has occurred. Consult your doctor or pharmacist for more details.

Do not take Rasburicase if you have a metabolic condition called glucose-6-phosphate dehydrogenase (G6PD) deficiency because it can severely damage your red blood cells, leading to anemia (hemolysis). If you are of African or Mediterranean descent, you may be at higher risk for G6PD deficiency and should be tested to see if you have this condition before starting Rasburicase .

Rasburicase can cause a condition that affects the ability of your red blood cells to carry oxygen (methemoglobinemia). Do not restart Rasburicase if this effect occurs. Consult your doctor for more details.

Rasburicase can interfere with accurate measurements of uric acid in the blood, resulting in falsely low levels. Be sure to tell all lab personnel that you are using Rasburicase .


Rasburicase is used for:

Preventing high blood levels of uric acid from occurring in children with cancer (eg, leukemia, lymphoma, solid malignant tumors) who are about to receive cancer chemotherapy treatment.

Rasburicase is a urate-oxidase enzyme. When chemotherapy is given, cancer cells are destroyed, releasing large amounts of uric acid into the blood. Rasburicase works by allowing uric acid to be more easily removed from the body by the kidneys.

Do NOT use Rasburicase if:

  • you are allergic to any ingredient in Rasburicase
  • you have a metabolic condition called G6PD deficiency or a history of methemoglobinemia (a bluish discoloration to the skin and mucous membranes) or hemolysis from using Rasburicase

Contact your doctor or health care provider right away if any of these apply to you.

Before using Rasburicase :

Some medical conditions may interact with Rasburicase . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have kidney disease or are dehydrated

Some MEDICINES MAY INTERACT with Rasburicase . However, no specific interactions with Rasburicase are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Rasburicase may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Rasburicase :

Use Rasburicase as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Rasburicase is usually administered as an infusion over 30 minutes at your doctor"s office, hospital, or clinic. Ask your doctor or pharmacist any questions that you may have about Rasburicase .
  • When Rasburicase is mixed, the vial should not be shaken.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
  • If Rasburicase contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • If you miss a dose of Rasburicase , contact your doctor immediately to establish a new dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Rasburicase .

Important safety information:

  • Rasburicase can interfere with the uric acid in blood samples when the blood samples are kept at room temperature. This can cause falsely low uric acid results. Inform all lab personnel that you are using Rasburicase , because they must follow special procedures to process your blood samples.
  • LAB TESTS, including uric acid levels, will be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Rasburicase with extreme caution in CHILDREN younger than 2 years of age because they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Rasburicase during pregnancy. It is unknown if Rasburicase is excreted in breast milk. Do not breast-feed while taking Rasburicase .

Possible side effects of Rasburicase :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; headache; mouth sores or ulcers; nausea; stomach pain; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blue or gray skin color; chest pain; chills; constipation; dark urine; fever; numbness or tingling of the skin; persistent sore throat; severe dizziness; shivering; weakness; yellowing of the eyes and skin.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately.

Proper storage of Rasburicase :

Rasburicase is usually handled and stored by a health care provider. If you are using Rasburicase at home, store Rasburicase as directed by your pharmacist or health care provider. Keep Rasburicase out of the reach of children and away from pets.

General information:

  • If you have any questions about Rasburicase , please talk with your doctor, pharmacist, or other health care provider.
  • Rasburicase is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Rasburicase . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition 06.4.1.002
Copyright © 2006 Wolters Kluwer Health, Inc.




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