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Some commonly used brand names are:
Vigabatrin (VYE-gab-a-trin) increases the amount of the brain chemical GABA. It is thought that epileptic seizures are the result of low levels of GABA. By increasing the amount of GABA, vigabatrin reduces the likelihood of an epileptic seizure.
This medicine is available only with your doctor"s prescription, in the following dosage forms:
Before Using This Medicine
In deciding to use a medicine, the risks of taking vigabatrin must be weighed against the good it will do. This is a decision you and your doctor will make. For vigabatrin, the following should be considered:
Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to vigabatrin. Also tell your health care provider if you are allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy— Studies have not been done in pregnant women. However, studies in rabbits have shown that vigabatrin causes birth defects. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.
Breast-feeding— It is not known if vigabatrin passes into breast milk. Because of the risk of unwanted effects in the nursing infant, breast-feeding is not recommended.
Children—This medicine has been tested in children and, in effective doses, has not been shown to cause different problems than it does in adults.
Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of vigabatrin in the elderly with use in other age groups.
Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are using any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Other medical problems—The presence of other medical problems may affect the use of vigabatrin. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This Medicine
Dosing—The dose of vigabatrin will be different for different patients. Follow your doctor"s orders or the directions on the label . The following information includes only the average doses of vigabatrin. If your dose is different, do not change it unless your doctor tells you to do so.
Missed dose— If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage—To store this medicine:
Precautions While Using This Medicine
It is important that you visit your physician .
If you will be taking this medicine for a long time, it is very important that your eye doctor check you approximately every 3 months for any visual problems.
If your symptoms do not improve or if they become worse, check with your doctor.
Do not take other medicines unless they have been discussed with your doctor.
This medicine may cause some people to become drowsy, dizzy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy, drowsy, or not alert, .
Do not suddenly stop taking this medicine without first checking with your doctor. Your doctor may want to reduce your dose gradually. Stopping this medicine suddenly may cause seizures.
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Amnesia; blurred vision; blue-yellow color blindness; decreased vision or other vision changes; eye pain; increase in seizures
Less common or rare
Uncontrolled rolling eye movements
Symptoms of overdose
Get emergency help immediately if any of the following symptoms of overdose occur
Mood or mental changes
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome.
Abdominal pain; abnormal coordination; agitation; anxiety; clumsiness; confusion; constipation; mental depression; diarrhea; dizziness; drowsiness; double vision or seeing double; fatigue; hyperactivity ; increased movement; joint pain; burning, tingling, or prickly sensations ; shakiness; sleepiness or unusual drowsiness; trembling; tremor; unsteadiness
Aggression; concentration impaired; headache; increased saliva; insomnia; muscle weakness; nausea; speech disorder; thinking abnormal; vomiting; weight gain
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
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