Xolair

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Xolair, |Xolair

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Xolair

Generic Name: omalizumab (oh mah lye ZOO mab)
Brand Names: Xolair

What is omalizumab?

Omalizumab is an antibody that helps decrease allergic responses in the body.

Omalizumab is used to treat moderate to severe asthma that is caused by allergies.

Omalizumab is usually given after other asthma medications have been tried without successful treatment of symptoms.

Omalizumab may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about omalizumab?

Some people receiving omalizumab have had a severe, life-threatening allergic reaction to this medication. Allergic reactions to omalizumab usually occur within 2 hours after injection, but they have occurred up to 24 hours after the dose or longer in some people. Omalizumab allergic reactions may also occur after receiving any dose (first, second, third, etc.) even if you had no reaction to earlier injections of omalizumab. Get emergency medical help if you have any of these signs of an allergic reaction: hives or skin rash; difficulty breathing; feeling light-headed, fainting; swelling of your face, lips, tongue, or throat.

Asthma is often treated with a combination of different drugs. To best treat your condition, use all of your medications as directed by your doctor. Be sure to read the medication guide or patient instructions provided with each of your medications. Do not change your doses or medication schedule without advice from your doctor.

If you also use a steroid medication, do not stop using the steroid suddenly. Talk with your doctor if any of your asthma medications do not seem to work as well in treating or preventing asthma attacks. Your symptoms may not improve right away once you start receiving omalizumab. For best results, keep receiving the medication as directed. Talk with your doctor if your symptoms do not improve after a few weeks of treatment.

It is important to use omalizumab regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Using this medication may increase your risk of certain types of cancers of the breast, skin, prostate, or salivary gland. Talk to your doctor about your individual risk.

What should I discuss with my healthcare provider before using omalizumab?

Do not use this medication if you are allergic to omalizumab.

Before using omalizumab, tell your doctor if you have any other medical conditions or if you take other medicines. You may not be able to take omalizumab or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Omalizumab may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use omalizumab?

Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor.

Omalizumab is given as an injection under the skin. Your doctor, nurse, or other healthcare provider will give you this injection. Omalizumab is usually given every 2 or 4 weeks.

You may be given instructions on how to inject your medicine at home. Do not use this medicine at home if you do not fully understand how to give the injection and properly dispose of needles and syringes used in giving the medicine.

Use each needle and syringe only one time. Throw away used needles and syringes in a puncture-proof container. If your medicine does not come with such a container, ask your pharmacist where you can get one. Keep this container out of the reach of children and pets. Your pharmacist can tell you how to properly dispose of the container.

Omalizumab will not treat an asthma attack that has already begun. It does not work fast enough to reverse the symptoms of an attack of asthma or bronchospasm. Use only a fast-acting inhalation medication to treat an asthma attack.

Asthma is often treated with a combination of different drugs. To best treat your condition, use all of your medications as directed by your doctor. Be sure to read the medication guide or patient instructions provided with each of your medications. Do not change your doses or medication schedule without advice from your doctor.

If you also use a steroid medication, do not stop using the steroid suddenly. Talk with your doctor if any of your asthma medications do not seem to work as well in treating or preventing asthma attacks. Your symptoms may not improve right away once you start receiving omalizumab. For best results, keep receiving the medication as directed. Talk with your doctor if your symptoms do not improve after a few weeks of treatment.

It is important to use omalizumab regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

To be sure this medication is helping your condition, your doctor may want you to have allergy tests and lung function tests on a regular basis. Do not miss any scheduled visits to your doctor.

Store omalizumab in the refrigerator but do not allow it to freeze.

What happens if I miss a dose?

Contact your doctor if you miss a dose of omalizumab.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

An overdose of omalizumab is not likely to produce life-threatening symptoms.

What should I avoid while using omalizumab?

There are no restrictions on food, beverages, or activity while using omalizumab unless your doctor has told you otherwise.

Omalizumab side effects

Some people receiving omalizumab have had a severe, life-threatening allergic reaction to this medication. Allergic reactions to omalizumab usually occur within 2 hours after injection, but they have occurred up to 24 hours after the dose or longer in some people. Omalizumab allergic reactions may also occur after receiving any dose (first, second, third, etc.) even if you had no reaction to earlier injections of omalizumab. Get emergency medical help if you have any of these signs of an allergic reaction: hives or skin rash; difficulty breathing; feeling light-headed, fainting; swelling of your face, lips, tongue, or throat.

Other serious side effects include easy bruising or bleeding, or unusual weakness.

Less serious side effects may be more likely to occur, such as:

  • pain;

  • tired feeling;

  • joint or muscle pain;

  • dizziness;

  • ear pain;

  • hair loss;

  • mild itching or skin rash; or

  • redness, bruising, warmth, burning, stinging, itching, pain, or swelling of your skin where the injection was given.

  • sore throat or cold symptoms.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect omalizumab?

There may be other drugs that can affect omalizumab. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist has information about omalizumab written for health professionals that you may read.

What does my medication look like?

Omalizumab is available with a prescription under the brand name Xolair. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 1.03. Revision Date: 03/07/2007 14:42:16.




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