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LOTEPREDNOL AND TOBRAMYCIN (Ophthalmic)†
Some commonly used brand names are:
In the U.S.—
Loteprednol (loe-te-PRED-nol) and tobramycin (toe-bra-MYE-sin) is a combination of an antibiotic and a corticosteroid (kor-ti-ko-STER-oid). It is used in the eye to prevent permanent damage, which may occur with certain eye problems.
This medicine is available only with your doctor"s prescription, in the following dosage forms:
Before Using This Medicine
In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For loteprednol and tobramycin, the following should be considered:
Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to loteprednol or tobramycin. Also tell your doctor and pharmacist if you are allergic to any other substances, such as other corticosteroids or aminoglycosides.
Pregnancy—Loteprednol and tobramycin combination has not been studied in pregnant women. However, studies in animals have shown that loteprednol may cause unwanted effects. Before taking this medicine, make sure you doctor knows if you are pregnant or if you may become pregnant.
Breast-feeding—It is not known whether loteprednol and tobramycin combination passes into the breast milk. Loteprednol and tobramycin combination is not recommended during breast-feeding, because it may cause unwanted effects in nursing babies.
Children—Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of loteprednol and tobramycin in children with use in other age groups.
Older adults—This medicine has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults.
Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Other medical problems—The presence of other medical problems may affect the use of loteprednol and tobramycin combination. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This Medicine
Shake the container very well before applying the eye drops.
Using only if the imprinted neckband is intact.
Do not wear soft contact lenses while you are using this medicine. .
Decrease use gradually as symptoms improve.
To help clear up your eye infection completely, keep using loteprednol and tobramycin for the full time of treatment , even if your symptoms have disappeared.
Dosing—The dose of ophthalmic loteprednol and tobramycin will be different for different patients. Follow your doctor"s orders or the directions on the label . The following information includes only the average doses of loteprednol and tobramycin. If your dose is different, do not change it unless your doctor tells you to do so.
Missed dose—If you miss a dose of this medicine, use it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage—To store this medicine:
Precautions While Using This Medicine
If you will be using this medicine for more than few weeks, an ophthalmologist (eye doctor) should examine your eyes at regular visits to make sure it does not cause unwanted effects.
If your eye infection does not improve or if your condition becomes worse, check with your doctor .
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Increased intraocular pressure; painful irritation of the clear front part of the eye
Blurred vision or blue-green halos seen around objects; blurred vision or other changes in vision; decreased vision; discharge from the eye; dry eyes; eyelid burning, redness, itching, pain, or tenderness; fast heartbeat; fever; hives; hoarseness; irritation and swelling of the eye; itching; joint pain; lid itching and swelling; pain in eye; rash; redness of skin; redness of eyelid; sensitivity of eyes to light; shortness of breath; stiffness or swelling; swelling of eyelids, face, lips, hands, or feet; tightness in chest; troubled breathing or swallowing; wheezing
Incidence not known
Redness of eye; tearing
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome.
Burning; dry eyes; headache; increased sensitivity of eyes to light; itching; stinging
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
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